Emerging nanoscopy for single entity characterisation

用于单一实体表征的新兴纳米技术

• 批准号: EP/X038017/1
• 负责人: Yanling Tian
• 金额: $ 30.81万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX038017%2F1
• 关键词: Emerging; nanoscopy; single; entity; characterisation

The capability of interpreting phenomena at the nanoscale level has led to an unprecedented and refined understanding of structures and mechanisms of single entities. This has brought a new era across the fields of biomedicine, biophysics and biomaterial nanoscience, and thus revise our previous concepts on cellular structures and nanoscale electronics. These technologies bear an enormous potential to transform not only the advancement of our knowledge, but also the development of diagnostic/prognostic approaches. However, we currently lack the ability to conduct correlative imaging at this challenging dimension while directly linking the nanoscale mechanical, physical and electrical parameters with macroscopic phenomena. Therefore, it is timely and important to explore innovative measurement and imaging methods, which could overcome the limitations of conventional routes and become enabling technologies for the second correlative nanoscopy revolution. The proposed 'Emerging nanoscopy for single entity characterisation (ENSIGN)' project is such a novel approach, which seeks to develop a transformational, integrated approach for single entity imaging and characterisation. ENSIGN will develop and combine high speed force, electrical, and microwave nanoscopy with optical and electron nanoscopy, to provide a quantitative, simultaneous multiparameter measurement, high speed and cost-effective beyond state-of-the-art capabilities for next generation single entity imaging, electrochemistry, mechanobiology and biomechanics. The developed nanoscopy will have unprecedented high resolution, multi-modal and multi-dimensional simultaneous imaging capabilities and be quantitative, fast and non-invasive. The obtained advanced technique will form a cornerstone for the advancement of cell biology, nanomaterials, and next generation battery, and thus keep Europe's leading position in the world for potential major scientific and technological breakthroughs in these research areas.

在纳米级层面解释现象的能力导致对单个实体的结构和机制的前所未有且精致的理解。这为生物医学，生物物理学和生物材料纳米科学领域带来了一个新时代，从而修改了我们先前关于细胞结构和纳米级电子的概念。这些技术具有巨大的潜力，不仅可以改变我们知识的发展，还可以发展诊断/预后方法的发展。但是，我们目前缺乏在这个具有挑战性的维度上进行相关成像的能力，同时将纳米级的机械，物理和电参数与宏观现象联系起来。因此，探索创新的测量和成像方法是及时且重要的，这可以克服常规途径的局限性并成为第二次相关纳米镜革命的促成技术。提出的“单一实体表征的新兴纳米镜检查”（少尉）项目是一种新颖的方法，它试图开发一种用于单个实体成像和表征的转化，综合方法。少尉将与光学和电子纳米镜一起发展并结合高速力量，电气和微波纳米镜检查，以提供定量的，同时的多参数测量，高速和具有成本效益的下一代单实体成像，电学位，机械方法和生物力学的最新能力。开发的纳米镜检查将具有前所未有的高分辨率，多模式和多维同时成像功能，并且具有定量，快速和无创的。获得的先进技术将构成细胞生物学，纳米材料和下一代电池的发展的基石，从而使欧洲在这些研究领域的潜在主要科学和技术突破中保持领先地位。

项目成果

Use of Atomic Force Microscopy in UVB-Induced Chromosome Damage Provides Important Bioinformation for Cell Damage Assessment.

• DOI: 10.1021/acs.langmuir.3c01644
• 发表时间: 2023-09
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Bowei Wang;Jianjun Dong;Fan Yang;Tuoyu Ju;Jiani Li;Junxiang Wang;Ying Wang;M. J. C. Crabbe;Yuandong Tian;Zuobin Wang

Relative sensitivity of nano-mechanical cantilevers to stiffness and mass variation

• DOI: 10.1016/j.ijmecsci.2023.108728
• 发表时间: 2023-12-21
• 期刊: INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
• 影响因子: 7.3
• 作者: Yang，Yue;Tian，Yanling;Song，Yumeng
• 通讯作者: Song，Yumeng