NUTRITION AND CHRONIC DISEASE

营养与慢性病

• 批准号: 3745049
• 负责人: KOUDY WILLIAMS
• 金额: --
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745049
• 关键词: Indonesia; Macaca fascicularis; animal breeding; atherosclerosis; blood chemistry; cardiovascular disorder prevention; cooperative study; coronary disorder; dietary supplements; estrogens; female; health care; health care model; hormone therapy; low density lipoprotein; mature animal; model design /development; nutrition related tag; postmenopause; tocopherols; vitamin therapy; women's health

This project seeks to establish the mechanisms for collaborative research between the Institute Pertanian Bogor (IPB) in Indonesia and the CMCRC in the broad area of nutrition and chronic disease. This study is the first in a series of planned collaborations between the two institutions. Our programmatic aims in this project are: 1) to establish an artery histomorphometry laboratory at the IPB, and 2) to provide a unique training opportunity for postdoctoral fellows at the CMCRC and for Indonesian veterinarians. Our scientific aims are: l) to compare the effects of estrogen replacement therapy (Premarin) and vitamin E supplementation on progression of coronary artery atherosclerosis in surgically postmenopausal female cynomolgus monkeys, and 2) to determine if the therapeutic effects of either regimen are associated with effects on low-density lipoprotein oxidation.

该项目旨在建立合作研究机制 印度尼西亚茂物 Pertanian Institute (IPB) 与 CMCRC 之间 在营养和慢性病的广泛领域。这项研究是 这是两个机构之间一系列计划合作中的第一个。 我们在这个项目中的计划目标是：1）建立一条动脉 IPB 的组织形态计量学实验室，以及 2) 提供独特的 为 CMCRC 博士后研究员提供培训机会 印度尼西亚兽医。我们的科学目标是： l) 比较 雌激素替代疗法（倍美力）和维生素 E 的作用 补充剂对冠状动脉粥样硬化进展的影响 对绝经后雌性食蟹猴进行手术，2) 确定 如果任一方案的治疗效果与效果相关 低密度脂蛋白氧化的影响。