Technology-driven combinatorial therapy to rewire the spinal cord after injury (ReWire)

技术驱动的组合疗法可在损伤后重新连接脊髓 (ReWire)

• 批准号: EP/X030946/1
• 负责人: Simone Di Giovanni
• 金额: $ 33.8万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX030946%2F1
• 关键词: Technology; driven; combinatorial; therapy; rewire

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish corticalcontrol over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural "wired" connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.

REWIRE将结合创新的翻译神经技术和康复干预措施，以修复和恢复脊髓（SC）后神经功能的修复和恢复。拟议的研究计划将为下一代科学家提供独特的技能，以为麻痹患者开发破坏性治疗解决方案。最近的技术突破引发了旨在恢复脊髓损伤（SCI）功能的疗法概念的范式转移。新型的药物输送系统和生物材料桥已被设计为减少继发性损伤和疤痕，以刺激和引导整个病变部位的神经纤维再生，并促进与完整的组织的功能重新连接。另外，神经调节疗法可以重新激活SCI以下的脊柱回路，使患有慢性麻痹的人重新获得自愿控制步行。结合康复，促进了神经系统恢复，该神经系统恢复在没有神经调节的情况下持续存在，这表明临床前模型所证明的SC的重新布线。为了绕过损伤，神经调节已与脑信号联系在一起，通过采用电神经刺激和机器人系统来重新建立脊柱回路的皮质孔孔。机器人技术的进步大大通过诱导新的自然“有线”连接来大大增加神经康复的影响。重新布线的目的是利用多个博士学位项目的框架中利用所有这些技术和治疗性突破，这些框架将不断相互作用，从而融合了SCI的有效组合治疗。 Rewire将重点关注三个编织的目标：i）建立一个国际，跨学科和部门教育网络，ii）建立一个SCI临床数据平台，以及，iii）将欧洲定位在SCI治疗的最前沿。