FACILITY FOR STUDY OF INFECTIOUS AGENTS AND VACCINES

传染媒介和疫苗研究设施

基本信息

批准号：
3595127
负责人：
MARY LOU CLEMENTS
金额：
$ 5万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-12-01 至 1991-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3595127
关键词：
Paramyxoviridae disease Paramyxovirus Pneumovirus Pneumovirus vaccine Rotavirus acute infectious nonbacterial gastroenteritis antiviral agents child (0-11) host organism interaction human subject human therapy evaluation immunological substance influenza influenza vaccines microorganism immunology rotavirus vaccines vaccinia virus virulence

项目摘要

The main aim of the LID is to understand the pathogenesis of important respiratory and enteric viral pathogens of humans and to develop means to prevent illness caused by these viruses. The purpose of the new contract is to provide volunteers and a facility in which to study the biology of medically important viruses in humans, to examine the hosts immune response to these viruses, and to test new candidate live virus vaccines for safety, genetic stability, immunogenicity, transmissibility and protective efficacy. Studies will also include administration of wild type viruses to volunteers in order to assess virulence. Subsequently, these wild type viruses will be used to challenge vaccinated volunteers in order to assess the extent of immunity induced by candidate vaccines. Studies with vaccines will include an evaluation of their safety, immunogenicity, transmissibility, and protective efficacy. These studies will include both adult and pediatric subjects since the viruses studied cause disease in both these populations; e.g., influenza A viruses cause severe respiratory disease in the elderly and, conversely, respiratory syncytial virus causes severe respiratory disease in infants. In summary, the new contract facility will provide facilities and populations to study the biology and immunology of a variety of viral pathogens and will serve as a testing center for the development of new vaccines effective against these agents.

LID 的主要目的是了解重要疾病的发病机制人类呼吸道和肠道病毒病原体，并开发方法预防由这些病毒引起的疾病。新合同的目的是提供志愿者和研究生物学的设施人类医学上重要的病毒，用于检查宿主的免疫反应针对这些病毒，并测试新的候选活病毒疫苗的安全性，遗传稳定性、免疫原性、传播性和保护性功效。研究还将包括使用野生型病毒志愿者以评估毒力。随后，这些野生型病毒将用于挑战接种疫苗的志愿者，以评估候选疫苗诱导的免疫程度。研究与疫苗将包括对其安全性、免疫原性、传播性和保护功效。这些研究将包括成人和儿童受试者，因为研究的病毒会在这两个人群中引起疾病；例如甲型流感病毒会导致老年人出现严重的呼吸道疾病，相反，呼吸道合胞病毒会导致婴儿严重的呼吸道疾病。总之，新合同设施将提供设施和研究多种病毒的生物学和免疫学病原体，并将作为开发新病原体的测试中心对这些病原体有效的疫苗。