SYNTHESIS OF RADIOSENSITIZING AGENTS

放射增敏剂的合成

• 批准号: 3607995
• 负责人: WILLIAM R WILSON
• 金额: $ 20.67万
• 依托单位: UNIVERSITY OF AUCKLAND
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1993-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3607995
• 关键词: chemical synthesis; drug quality /standard; drug screening /evaluation; laboratory mouse; neoplasm /cancer radiation therapy; radiopharmacology; radiosensitizer

The objective of this project is to develop the leads which result from the contract effort (N01CM67868) concerned with the screening of compounds for radiosensitizing activity. Analogs of the lead compounds will be synthesized and tested in vitro. The analogs will be developed using the knowledge of the relationship between molecular structure and radiosensitizing effectiveness which has accumulated from past and current studies. New and/or novel radiosensitizers for introduction into the clinic are expected from the proposed project.

该项目的目的是发展由 合同工作（N01CM67868）与化合物的筛选有关 用于放射敏感活性。 铅化合物的类似物将是 合成并在体外测试。 类似物将使用 了解分子结构与 从过去和现在积累的放射敏化有效性 研究。 新的和/或新颖的放射敏剂，用于引入 拟议项目的期望是诊所。