How age & sex impact the transcriptional control of mammalian muscle growth

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• 批准号: DP240100408
• 负责人: Prof Paul Gregorevic
• 金额: $ 59.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100408
• 关键词: How; age; sex; impact; transcriptional

Maintaining healthy muscle is crucial throughout all stages of life. Aging is associated with the loss of muscle and older muscles are resistant to growth due to age-related changes in gene expression and responsiveness. Many genes are expressed differently in male versus female muscle, which may have implications for sex-differences in muscle growth and aging. This project will generate new knowledge on which genes and biological pathways are crucial in determining mammalian muscle size and growth across the lifespan and between the sexes. Application of this knowledge may lead to future approaches to enable a healthy start to life and promote healthy aging in Australians and have implications for agriculture and muscle as a food source.

在生活的所有阶段，保持健康的肌肉至关重要。衰老与肌肉的丧失有关，较旧的肌肉由于基因表达和反应性的年龄变化而抵抗生长。许多基因在雄性肌肉和女性肌肉中的表达方式不同，这可能对肌肉生长和衰老的性别差异有影响。该项目将产生新的知识，这些知识在确定整个生命周期以及性别之间的哺乳动物肌肉大小和生长方面至关重要。这种知识的应用可能会导致未来的方法，使生活成为健康的开始并促进澳大利亚人的健康衰老，并对农业和肌肉作为食物来源有影响。