Process Control and Novel Materials for the Reactive Jet Impingement Process

反应射流冲击过程的过程控制和新型材料

• 批准号: EP/V013092/1
• 负责人: Kenneth Dalgarno
• 金额: $ 145.9万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FV013092%2F1
• 关键词: Process; Control; Novel; Materials; Reactive

Biofabrication techniques are used to process natural and synthetic biomaterials, for example including cells, proteins and drugs, in order to create living, tissue engineered structures. These structures are being used to research the development of new drugs and cell-based therapies for a wide range of medical conditions.This research proposal focuses on a new 3D printing technique called Reactive Jet Impingement (ReJI) which can be used for biofabrication. The ReJI technique has some advantages over existing techniques in terms of the number of cells it can deposit within a certain volume, and in terms of the range of the materials and shapes which it can print on. The research programme will focus on three things: (i) Improving the technology, by developing a computational model of the process to support and inform experimental studies, and through scaling up the technology in terms of print capability.(ii) Extending the range of materials which can be processed using the technology.(iii) Applying the technology to the development of clinically relevant tissue models for two selected application areas in drug testing for liver cancer and cardiac tissue engineering.

生物制造技术用于加工天然和合成生物材料，例如细胞、蛋白质和药物，以创建活的组织工程结构。这些结构被用于研究针对多种医疗状况的新药和基于细胞的疗法的开发。该研究提案重点关注一种称为反应喷射冲击（ReJI）的新型 3D 打印技术，该技术可用于生物制造。与现有技术相比，ReJI 技术在一定体积内可沉积的细胞数量以及可打印的材料和形状范围方面具有一些优势。该研究计划将重点关注三件事：(i) 通过开发支持和指导实验研究的过程计算模型来改进技术，并扩大打印能力方面的技术。(ii) 扩大打印范围(iii)将该技术应用于肝癌药物测试和心脏组织工程两个选定应用领域的临床相关组织模型的开发。

项目成果

Analysis and optimisation of mixing in binary droplet collisions

二元液滴碰撞混合分析与优化

• DOI: http://dx.10.1017/jfm.2023.749
• 发表时间: 2023
• 期刊: Journal of Fluid Mechanics
• 影响因子: 3.7
• 作者: Ruiz