EFFECTS OF MATERNAL PKU ON PREGNANCY OUTCOME

母亲 PKU 对妊娠结局的影响

• 批准号: 3650834
• 负责人: REUBEN MATALON
• 金额: $ 3.34万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-05-16 至 1991-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3650834
• 关键词: academic achievement; child (0-11); child physical development; child psychology; diet therapy; embryo /fetus; homozygote; human population genetics; human subject; mother /embryo /fetus nutrition; nutrition disorder chemotherapy; nutrition related tag; perinatal; phenylalanine; phenylketonurias

The level of maternal phenylalanine which will maintain a normal pregnancy. At what stage of pregnancy a low phenylalanine diet is most effective in preventing the effects of maternal PKU on the developing fetus. If the beneficial effects of a low phenylalanine diet can be improved when initiated prior to conception compared to post-conception. Whether the diet reduces the frequency of mental retardation, spontaneous abortions, low birth weight,congenital malformations, neurological and behavioral impairment found in infants of mothers with hyperphenylalaninemia.The levels of tyrosine and trace metals during pregnancy and ascertain the effects of supplementation if levels are found to be low on pregnancy outcome.

母体苯丙氨酸的水平将保持正常妊娠。 在怀孕的哪个阶段，低苯丙氨酸饮食最有效 防止母体PKU对发育中的胎儿的影响。 如果是 当低苯丙氨酸饮食的有益作用可以改善 与概念后相比，在受孕之前开始。 是否 饮食降低了智力低下的频率，自发堕胎， 低出生体重，先天性畸形，神经和行为 在患有苯基丙氨酸血症的母亲的婴儿中发现的障碍。 怀孕期间的酪氨酸和微量金属水平 补充的影响如果发现怀孕的水平很低 结果。