ELECTROPHORETIC GERMINAL MUTATION TEST DEVELOPMENT

电泳生发突变测试开发

• 批准号: 3639349
• 负责人: MICHAEL SHELBY
• 金额: $ 0.47万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-12-01 至 1985-03-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3639349
• 关键词: biological models; dosage; electrophoresis; germ cells; histology; mutagen testing; mutagens; nitrosourea; toxicant screening

This contract on the mouse electrophoretic germinal mutation assay is an integral part of the Cellular and Genetic Toxicology Branch's program in mammalian germ cell mutagenesis testing.

这项在小鼠电泳生发突变测定法上的合同是 细胞和遗传毒理学分支机构的整体部分 哺乳动物生殖细胞诱变测试。

项目成果

Dominant visible and electrophoretically expressed mutations induced in male mice exposed to ethylene oxide by inhalation.

通过吸入暴露于环氧乙烷的雄性小鼠诱导显性可见和电泳表达的突变。

• DOI: 10.1002/em.2860080609
• 发表时间: 1986
• 期刊: Environmental mutagenesis
• 作者: Lewis,SE;Barnett,LB;Felton,C;Johnson,FM;Skow,LC;Cacheiro,N;Shelby,MD
• 通讯作者: Shelby,MD

Hematology of a murine beta-thalassemia: a longitudinal study.

鼠β-地中海贫血的血液学：一项纵向研究。

• DOI: 10.1111/j.1749-6632.1985.tb17213.x
• 发表时间: 1985
• 期刊: Annals of the New York Academy of Sciences
• 影响因子: 5.2
• 作者: Popp,RA;Popp,DM;Johnson,FM;Skow,LC;Lewis,SE
• 通讯作者: Lewis,SE

Differential expression of murine adult hemoglobins in early ontogeny.

小鼠成年血红蛋白在个体发育早期的差异表达。

• 发表时间: 1985
• 期刊: Progress in clinical and biological research
• 作者: Wawrzyniak,CJ;Lewis,SE;Popp,RA
• 通讯作者: Popp,RA

A mutation in the beta-globin gene detected in the progeny of a female mouse treated with ethylnitrosourea.

在接受乙基亚硝基脲治疗的雌性小鼠的后代中检测到β-珠蛋白基因突变。

• DOI: 10.1073/pnas.82.17.5829
• 发表时间: 1985
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Lewis,SE;Johnson,FM;Skow,LC;Popp,D;Barnett,LB;Popp,RA
• 通讯作者: Popp,RA