IN VITRO EVALUATION OF CHEMICALS FOR IN VIVO TESTING

用于体内测试的化学品的体外评估

• 批准号: 3633247
• 负责人: RICHARD H SAN
• 金额: $ 3.61万
• 依托单位: MICROBIOLOGICAL ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-08-14 至 1990-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3633247
• 关键词: bioassay; carcinogen testing; chemical carcinogen; hamsters; laboratory rat

Contracts for Ames Salmonella assay support and Mouse Lymphoma assay support are required by the Office of the Director, DCE for its support of extramural and intramural activities of the Division. The primary thrust has been to support the NCI selection process for carcinogenicity testing in the National Toxicology Program (NTP). The NCI, and specifically DCE, plays a major role in nominating chemical candidates for carcinogenicity testing by the NTP, a responsibility the NCI retained when the bioassay program developed by this Division was transferred to the NTP in 1978. This Division has evolved a format to look at large groupings of chemicals (by structure or use category) to systematically select the best candidates. This has routinely shown that there is a paucity of in vitro data on most of the compounds, and of our 75 nominations over the last five years, 50 were tested in these two assays to supply the necessary information. Data obtained from the existing in vitro contracts has thus permitted our selection group to make more informed choices in a timely fashion.

Ames沙门氏菌测定和鼠标的合同 淋巴瘤测定支持是由 DCE主任对壁外和室内的支持 该部门的活动。 主要的推力是支持 NCI选择过程的致癌性测试 国家毒理学计划（NTP）。 NCI，特别是 DCE，在提名化学候选物的主要作用 NTP的致癌性测试，NCI的责任 当该部门开发的生物测定计划时保留 1978年被转移到NTP。该分裂已经进化 格式查看大量化学品（按结构或 使用类别）系统选择最佳候选人。 这 常规表明，在体外数据很少 大多数化合物，以及我们的75个提名 五年，在这两种测定中测试了50个，以提供 必要的信息。 从现有的体外获得的数据 因此，合同使我们的选拔小组能够使更多 及时明智的选择。