EVALUATION OF IMMUNE ABNORMALITIES IN AIDS

艾滋病免疫异常的评估

• 批准号: 3594604
• 负责人: J GEORGE BEKESI
• 金额: $ 13.57万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3594604
• 关键词: AIDS; cell sorting; cellular immunity; disease /disorder proneness /risk; helper T lymphocyte; homosexuals; human tissue; immunopathology; immunopathology chemotherapy; immunopathology diagnosis; leukocyte activation /transformation; lymphocyte; lymphokines; membrane activity; monoclonal antibody; suppressor T lymphocyte; young adult human (21-34)

This acquisition is for the immune monitoring of patients with AIDS and with populations with high risk of developing AIDS. Specifically, this acquisition involves the biological assessment of cellular function in those populations in which subset specification and activation markers are identified and will be conducted in two phases. Phase one will bea quarterly assessment of prospective controlled immunologic monitoring of peripheral lymphocyte and non-lymphocyte cellpopulations of AIDS patients. Phase two will be the assessment of cell functions, on a quarterly basis, using monoclonal antibodies to selectively remove different cell populations, and assaying the functions of the remaining cellpopulations.

此次收购用于对艾滋病患者的免疫监测和 人口具有高风险发展艾滋病的风险。 具体来说，这是 获取涉及对细胞功能的生物学评估 那些子集规范和激活标记的人群 确定并将分为两个阶段。 第一阶段将BEA 预期受控免疫监测的季度评估 艾滋病患者的外周淋巴细胞和非淋巴细胞细胞群。 第二阶段将是每季度对细胞功能的评估 使用单克隆抗体选择性去除不同的细胞 种群，并分析其余细胞组合的功能。