Dial-a-membrane: precision engineering of sub-micron self-assembled materials

Dial-a-membrane：亚微米自组装材料的精密工程

基本信息

批准号：
EP/V048651/1
负责人：
Yuval Elani
金额：
$ 25.78万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2021
资助国家：
英国
起止时间：
2021 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FV048651%2F1
关键词：
Dial membrane precision engineering sub

项目摘要

Liposomes and related amphiphilic assemblies have received much interest in recent years due to their wide biotechnological potential. This ranges from their use as capsules for targeted drug and vaccine delivery, miniaturised bioreactors, biosensors, tools for pharmacokinetic screens, and as cell models for the study of fundamental biology. They are increasingly being functionalised with biological machinery, which has led to them being exploited as the base motif for artificial cells: structures that mimic biological cells in form/function, which can perform user-defined tasks as biomimetic microdevices.Liposomes used in these applications share a common structure, namely that of a spherical compartment encased by a lipid bilayer. This lack of architectural diversity has hindered their technological potential. However, we know from biology that step changes in the sophistication of chemical microsystems can be achieved by having non-uniform spatial organisation; this is achieved through compartmentalisation of content in discrete spatial locations.In this project, we will develop new platform technologies which will enable a host of compartmentalised nanostructures that can be made-to-order, with full control over all relevant parameters including size, compartment number, and composition/phase state of individual compartments and their associated membranes. Once established, this new paradigm has the potential to underpin a host of applications in biotechnology, and provide new insights on fundamental biology through the use of biomimetic models that cannot yet be replicated in-vitro despite being pivotal to life. We will exploit the control afforded by this approach to create stimuli-responsive particles for in-situ drug synthesis as well as multi-stage therapeutic payload release, paving the way for industrial and clinical applications.

脂质体和相关的两亲集团近年来由于其广泛的生物技术潜力而引起了极大的兴趣。这包括它们用作靶向药物和疫苗输送的胶囊，微型生物反应器，生物传感器，用于药代动力学筛查的工具，以及用于研究基本生物学研究的细胞模型。它们越来越多地通过生物机械功能化，这导致它们被利用为人造细胞的基础主题：模仿形式/功能的生物细胞的结构，可以执行用户定义的任务作为生物映射的微型电视。在这些应用中使用的liposicomes，在这些应用中使用的liposyss共享一个常见的结构，即由一个常见的结构，即由canventalical cansphartics centecass a lipid bilay lipid bilay bilay bilay bilay bilay。缺乏建筑多样性阻碍了他们的技术潜力。但是，我们从生物学中知道，可以通过具有不均匀的空间组织来实现化学微系统复杂性的步骤变化。这是通过离散空间位置中内容的隔室化来实现的。在此项目中，我们将开发新的平台技术，这些技术将使可以按订单进行多种隔层纳米结构，并完全控制所有相关参数，包括大小，隔板数量，组合数和各个隔离室和相关骨膜的组成/相位状态。建立后，这种新的范式有可能支持生物技术中的众多应用，并通过使用仿生模型来对基本生物学提供新的见解，这些模型尽管对生命至关重要，但仍无法在体外复制。我们将利用这种方法为创建刺激性反应性颗粒提供的原位药物合成以及多阶段治疗有效载荷释放的控制，为工业和临床应用铺平了道路。