MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 3560155
• 负责人: CHARLES R BAUER
• 金额: $ 75.21万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3560155
• 关键词: cooperative study; female; human pregnant subject; human subject; human therapy evaluation; longitudinal human study; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); nursery; obstetric nursing; pediatric nursing; perinatal; premature infant human; respirators; respiratory function; ultrasound echoencephalography

The primary objective of this submission is to re-apply for designation as one of the centers selected to participate in the Network of Neonatal Intensive Care Units. The University of Miami's Division of Neonatology possesses an adequate clinical patient population, outstanding clinical, laboratory and research facilities, and competent, dedicated personnel. It has an extensive research experience in individual investigative work as well as in large collaborative multicenter clinical trials. The University of Miami has actively participated in the initial 5 year cycle of the NICU Network. Although consistently ranking third in number of low birth weight neonatal admissions, they have consistently ranked first in total numbers of infants randomized into the first major network trial on prophylactic intravenous immunoglobulin administration. They have extensive previous experience in other large multi-center successful clinical trials, such as prenatal glucocorticoid administration (NHLBI), high frequency ventilation (NHLBI. and the infant health and development program (Robert Wood Johnson). They are dedicated to the underlying goal of the Network which is to evaluate both the safety and efficacy of new therapeutic modalities using large multi-site randomized clinical trials, as opposed to limited personal experience or preference. The University of Miami has access to a large maternal-fetal-neonatal population approximating 14,000 live-born deliveries per year. In addition, it serves as the tertiary regional referral center for an area encompassing over 40,000 births and it receives out of county referrals from Central and South America and the Caribbean. The Neonatal Special Care Center routinely runs a census exceeding 120-130%. The high-risk team now includes over 200 full-time personnel whose work is exclusively devoted to neonates and their families. The neonatology faculty possess a wide range of expertise in areas of pulmonary and developmental medicine, substance abuse and infectious and central nervous system disorders. A longterm multi-disciplinary developmental evaluation and intervention program is directed by the proposed P.I. The University of Miami, with its commitment to relevant clinical research, its existing population, facilities and personnel, and its proven record of successful collaboration over the last decade, has a strong desire to continue in the Neonatal ICU Network and to contribute to effectively addressing the complex diagnostic and therapeutic problems of the newborn.

此提交的主要目的是重新申请 作为选择参加新生儿网络的中心之一 重症监护病房。 迈阿密大学新生儿学系 拥有足够的临床患者人群，出色的临床， 实验室和研究设施，以及有能力的专门人员。 它在个人调查工作中具有丰富的研究经验 以及大型协作多中心临床试验。 这 迈阿密大学积极参加了最初的5年周期 NICU网络。 虽然一贯排名低的低 出生体重新生儿入院，他们一直排名第一 随机分为第一个主要网络试验的婴儿总数 预防性静脉免疫球蛋白给药。 他们有 在其他大型多中心成功方面的丰富经验 临床试验，例如产前糖皮质激素给药（NHLBI）， 高频通风（NHLBI和婴儿的健康与发展 计划（罗伯特·伍德·约翰逊）。 他们致力于基础目标 旨在评估新的安全性和功效的网络 使用大型多站点随机临床试验的治疗方式， 而不是个人经验或偏好有限。 大学 迈阿密可以使用大量的母亲妇女源人群 每年约有14,000个现场送货。 此外，它服务 作为涵盖区域的三级区域推荐中心 40,000个出生，并从中央县转介和 南美和加勒比海。 新生儿特别护理中心 通常，人口普查超过120-130％。 高风险团队现在 包括200多名全职工作人员，他们的工作专门专门用于 新生儿及其家人。 新生儿学教师拥有广泛的范围 肺和发育医学领域的专业知识，物质 虐待和感染和中枢神经系统疾病。 长期 多学科发展评估和干预计划是 由拟议的P.I指导迈阿密大学的承诺 对于相关的临床研究，其现有人群，设施和 人员及其在最后一次成功的合作记录 十年，人们强烈希望继续在新生儿ICU网络中继续 有效解决复杂的诊断和治疗性 新生儿的问题。