PEDIATRIC ONCOLOGY GROUP

儿科肿瘤组

• 批准号: 3556924
• 负责人: FAITH H KUNG
• 金额: $ 11.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3556924
• 关键词: 6 thiopurine; Burkitt's lymphoma; Ewing's tumor; Hodgkin's disease; asparaginase; brain neoplasms; cancer registry /resource; cancer rehabilitation mental health service; cellular oncology; child (0-11); combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytosine arabinoside; daunorubicin; doxorubicin; drug metabolism; fibrosarcoma; human subject; human therapy evaluation; liver neoplasms; methotrexate; mouse leukemia; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer classification /staging; neoplasm /cancer immunology; neoplasm /cancer radiation therapy; nephroblastoma; oncology nursing; pediatric neoplasm /cancer; prednisone; radiation therapy dosage; retinoblastoma; rhabdomyosarcoma; teratoma; testis neoplasms; thyroid neoplasm; vincristine

This proposal represents a request to support participation in the Pediatric Oncology Group (POG). This cooperative research is devoted to the investigation of chemotherapeutic approaches to acute leukemia and other neoplastic diseases of childhood. Significant palliation and prolongation of survival has been achieved and contributions have been made in clinical pharmacology. However, the real objective of these studies is the eradication of neoplastic diseases by treatment. Studies are being designed to reflect an increasing intensity of attack on the neoplastic cell. The cooperative group technique permits prompt evaluation in series of reasonable size of promising leads in chemotherapy. These leads or new approaches are often suggested by the results of the group's own work in clinical oncology. Thus, a completed protocol often suggests the new avenues to be explored in new protocols. In addition, protocols are designed to exploit maximal clinical or conceptual advances made in experimental animals and/or clinical pilot studies. The Division of Pediatric Hematology-Oncology in the Department of Pediatrics at the University of California, San Diego (UCSD) has a 10 year involvement in cooperative group studies with Cancer and Leukemia Group B prior to joining forces with the Pediatric Oncology Group in 1980. Between January 1, 1983 and December 31, 1984, we have had 129 patient registrations on 26 group protocol studies. In addition, the P.I. coordinated a Phase II study o n VP-16-213 and completed a draft on a Group Protocol study on the treatment of early stage Hodgkin's disease, and other UCSD investigators served as coordinators for Group Protocols on germ cell tumors, bone marrow transplantation for patients with ALL in second remission or involved in the laboratory investigation of Group Protocol studies in T-cell ALL or neuroblastoma. We plan to continue our active participation in all phases of POG activities.

该建议代表了支持参与的请求 小儿肿瘤学组（POG）。 这项合作研究致力于 研究急性白血病和化学治疗方法的研究 儿童时期的其他肿瘤疾病。 明显的侮辱和 已经实现了生存的延长，并做出了贡献 在临床药理学中。 但是，这些研究的真正目的是 通过治疗消除肿瘤疾病。 正在研究 旨在反映对肿瘤的攻击强度的增加 细胞。 合作小组技术允许串联评估 化学疗法中有前途的铅的合理大小。 这些线索或新的 该小组自己的工作的结果经常提出方法 临床肿瘤学。 因此，完整的协议通常建议新的 在新协议中探索的途径。 此外，协议是 旨在利用最大的临床或概念进步 实验动物和/或临床初步研究。 分裂 小儿血液学肿瘤学的儿科科学 加州大学圣地亚哥分校（UCSD）有10年的参与 加入之前，与癌症和白血病B组的合作小组研究 1980年在儿科肿瘤学小组中的力量。1983年1月1日之间 1984年12月31日，我们在26组上进行了129个患者注册 协议研究。 此外，P.I.协调II期研究 VP-16-213并完成了有关治疗的小组协议研究草案 早期霍奇金氏病和其他UCSD调查人员作为 关于生殖细胞肿瘤的组方案协调员，骨髓 所有二手缓解或参与的患者的移植 T细胞全部或 成神经细胞瘤。 我们计划继续积极参与各个阶段 POG活动。