PEDIATRIC ONCOLOGY GROUP

儿科肿瘤组

• 批准号: 3556924
• 负责人: FAITH H KUNG
• 金额: $ 11.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1980
• 资助国家: 美国
• 起止时间: 1980-07-01 至 1990-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3556924
• 关键词: 6 thiopurine; Burkitt's lymphoma; Ewing's tumor; Hodgkin's disease; asparaginase; brain neoplasms; cancer registry /resource; cancer rehabilitation mental health service; cellular oncology; child (0-11); combination cancer therapy; combination chemotherapy; cooperative study; cyclophosphamide; cytosine arabinoside; daunorubicin; doxorubicin; drug metabolism; fibrosarcoma; human subject; human therapy evaluation; liver neoplasms; methotrexate; mouse leukemia; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer classification /staging; neoplasm /cancer immunology; neoplasm /cancer radiation therapy; nephroblastoma; oncology nursing; pediatric neoplasm /cancer; prednisone; radiation therapy dosage; retinoblastoma; rhabdomyosarcoma; teratoma; testis neoplasms; thyroid neoplasm; vincristine

This proposal represents a request to support participation in the Pediatric Oncology Group (POG). This cooperative research is devoted to the investigation of chemotherapeutic approaches to acute leukemia and other neoplastic diseases of childhood. Significant palliation and prolongation of survival has been achieved and contributions have been made in clinical pharmacology. However, the real objective of these studies is the eradication of neoplastic diseases by treatment. Studies are being designed to reflect an increasing intensity of attack on the neoplastic cell. The cooperative group technique permits prompt evaluation in series of reasonable size of promising leads in chemotherapy. These leads or new approaches are often suggested by the results of the group's own work in clinical oncology. Thus, a completed protocol often suggests the new avenues to be explored in new protocols. In addition, protocols are designed to exploit maximal clinical or conceptual advances made in experimental animals and/or clinical pilot studies. The Division of Pediatric Hematology-Oncology in the Department of Pediatrics at the University of California, San Diego (UCSD) has a 10 year involvement in cooperative group studies with Cancer and Leukemia Group B prior to joining forces with the Pediatric Oncology Group in 1980. Between January 1, 1983 and December 31, 1984, we have had 129 patient registrations on 26 group protocol studies. In addition, the P.I. coordinated a Phase II study o n VP-16-213 and completed a draft on a Group Protocol study on the treatment of early stage Hodgkin's disease, and other UCSD investigators served as coordinators for Group Protocols on germ cell tumors, bone marrow transplantation for patients with ALL in second remission or involved in the laboratory investigation of Group Protocol studies in T-cell ALL or neuroblastoma. We plan to continue our active participation in all phases of POG activities.

该提案代表了支持参与的请求 儿科肿瘤学组 (POG)。 这项合作研究致力于 急性白血病化疗方法的研究 儿童期的其他肿瘤疾病。 显着的缓解作用和 已实现延长生存期并做出贡献 在临床药理学中。 然而，这些研究的真正目的是 通过治疗根除肿瘤性疾病。 研究正在进行中 旨在反映对肿瘤的攻击强度不断增加 细胞。 协作组技术允许快速进行系列评估 合理大小的有希望的化疗先导化合物。 这些线索或新线索 方法通常是由小组自己的工作结果提出的 临床肿瘤学。 因此，完整的协议通常会建议新的 新协议中需要探索的途径。 此外，协议是 旨在利用最大的临床或概念进步 实验动物和/或临床试点研究。 分部 儿科儿童血液肿瘤科 加州大学圣地亚哥分校 (UCSD) 参与了 10 年 加入之前与癌症和白血病 B 组进行合作小组研究 1980年与儿科肿瘤学组合作。1983年1月1日 截至1984年12月31日，我们已登记26组129名患者 协议研究。 此外，P.I.协调一项 II 期研究 VP-16-213 并完成了治疗组方案研究草案 早期霍奇金病的研究人员和加州大学圣地亚哥分校的其他研究人员担任 生殖细胞肿瘤、骨髓小组协议协调员 为第二次缓解或参与相关疾病的 ALL 患者进行移植 T 细胞 ALL 组方案研究的实验室调查或 成神经细胞瘤。 我们计划继续积极参与各个阶段 POG 活动。