CHILDRENS CANCER STUDY GROUP

儿童癌症研究小组

• 批准号: 3555705
• 负责人: JORGE A ORTEGA
• 金额: $ 57.78万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1993-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3555705
• 关键词: Ewing's tumor; Hodgkin's disease; acute leukemia; acute lymphocytic leukemia; antineoplastics; asparaginase; azacitidine; bleomycin; bone marrow transplantation; brain neoplasms; cancer rehabilitation mental health service; carcinogenesis inhibitor; cellular oncology; child (0-11); cis platinum compound; clinical trials; combination cancer therapy; combination chemotherapy; cooperative study; cytogenetics; cytosine arabinoside; disease /disorder model; doxorubicin; drug adverse effect; drug metabolism; germ cell neoplasms; hepatocellular carcinoma; human subject; human therapy evaluation; metastasis; myelogenous leukemia; neoplasm /cancer chemotherapy; neoplasm /cancer education; neoplasm /cancer epidemiology; neoplasm /cancer immunotherapy; neoplasm /cancer radiation therapy; neoplasm /cancer surgery; nephroblastoma; neuroblastoma; osteosarcoma; pediatric neoplasm /cancer; pediatric pharmacology; rhabdomyosarcoma; synchronous cell division

The project proposes continuation of a comprehensive pediatric oncology program at Childrens Hospital of Los Angeles (CHLA). This program is designed to improve the treatment of children with cancer by conducting clinical investigations as a member of the Childrens Cancer Study Group (CCSG) and by independently conducting other research which is directly related to the mission of CCSG. CHLA is a major pediatric referral center for the Pacific Southwest and has one of the largest pediatric oncology services in the nation. An interdepartmental program has developed which involves basic and clinical scientists and has evolved into a multidisciplinary model for the management of pediatric cancers. participation of CHLA investigators in CCSG enables quantitative comparative clinical investigations aimed at establishing the best mode of any cancer therapy. The unique resources of CHLA permit development of new therapeutic approaches for Group-wide application. These include participation in the NCI Phase I Working Group and the Late Effects Study Group, Brain Tumor Program, Bone and Extremity Tumor Program, the evaluation of new dose schedules and combinations of established agents predicted by in vitro and in vivo pharmacological studies, investigation of mechanisms of drug resistance, bone marrow transplantation, immunological characterization of selected neoplasms, effects of cancer and its treatment on hematopoiesis, intensive chemotherapy in the protected environment, optimum nutritional support in childhood malignancies, approaches to psychosocial rehabilitation of the pediatric cancer patient and family, education of caregivers and patients/families, epidemiology of childhood malignancies, late effects of cancer and its treatment, preclinical studies in molecular and cellular pharmacology, tumor cell biology, carcinogenesis and chemoprevention, cytogenetics, and in vitro and in vivo tumor model system. A network of community physicians participates in the CCSG Cooperative Group Outreach Program under the sponsorship of CHLA which enables the use of optimal therapy in children who are not referred for initial cancer care. Through the proposed renewal, the comprehensive program at CHLA will seek as its ultimate goal an integrated and investigative approach to childhood cancer.

该项目提议继续综合的小儿 洛杉矶儿童医院（CHLA）的肿瘤学计划。 这 计划旨在改善儿童的治疗 通过作为成员进行临床研究来进行癌症 儿童癌研究组（CCSG）和独立进行 与CCSG的使命直接相关的其他研究。 CHLA是西南太平洋的主要儿科转诊中心 并具有最大的儿科肿瘤科之一 国家。 开发了部门间计划，涉及 基本和临床科学家，已经演变为 小儿癌管理的多学科模型。 CHLA研究人员参与CCSG可以定量 比较临床研究旨在建立最佳 任何癌症疗法的模式。 CHLA许可证的独特资源 开发新的治疗方法 应用。 这些包括参与NCI阶段 工作组和后期效应研究组，脑肿瘤 程序，骨骼和肢体肿瘤计划，新的评估 由 体外和体内药理研究，研究 耐药性，骨髓移植机制， 选定肿瘤的免疫学表征， 癌症及其对造血的治疗，强化化疗 在受保护的环境中，最佳营养支持 童年的恶性肿瘤，社会心理康复方法 小儿癌症患者和家庭的教育 患者/家庭，儿童恶性肿瘤的流行病学，迟到 癌症及其治疗的影响，临床前研究 分子和细胞药理学，肿瘤细胞生物学， 致癌和化学预防，细胞遗传学以及体外和 体内肿瘤模型系统。 社区医生网络 参加CCSG合作集团外展计划 CHLA的赞助能够使用最佳疗法 在未转介初次癌症护理的儿童中。 通过 拟议的续约，CHLA的综合计划将寻求 作为其最终目标，一种综合和调查的方法 儿童癌。