Computational analysis of the influence of growth cone shape dynamics on axon guidance

生长锥形状动力学对轴突导向影响的计算分析

• 批准号: nhmrc : GNT1083707
• 负责人: Prof Geoffrey Goodhill
• 金额: $ 22.37万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/computational-analysis-influence-axon-guidance/1345522
• 关键词: Computational; analysis; influence; growth; cone

For the brain to function correctly its neurons must be connected correctly. This project will use a novel mathematical approach to understand how growing nerve fibres find where to go in the developing brain. In particular we will use both experiments and computational analysis to understand how the shape of the tip of a growing nerve fibre helps the fibre navigate. This may help us understand the biological cause of many different types of mental disorders.

为了使大脑正常运作，其神经元必须正确连接。该项目将使用一种新颖的数学方法来了解生长中的神经纤维如何在发育中的大脑中找到去向。特别是，我们将使用实验和计算分析来了解生长中的神经纤维尖端的形状如何帮助纤维导航。这可能有助于我们了解许多不同类型的精神障碍的生物学原因。