UTILIZATION OF THE IMMUNODEFICIENCY CANCER RESEARCH

免疫缺陷癌症研究的应用

• 批准号: 3548912
• 负责人: Alexandra H Filipovich
• 金额: $ 9.53万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3548912
• 关键词: Betaherpesvirinae; Epstein Barr virus; Hodgkin's disease; Wiskott Aldrich syndrome; ataxia telangiectasia; cancer information system; cancer registry /resource; chromosome aberrations; cytogenetics; histopathology; human T cell lymphotropic virus type 1; human immunodeficiency virus 1; human subject; immunodeficiency; longitudinal human study; lymphoma; neoplasm /cancer epidemiology; neoplasm /cancer genetics; patient /disease registry

The collection of rare cases of cancer in patients with naturally-occurring immunodeficiencies from around the world has permitted investigators at the Immunodeficiency Cancer Registry (ICR) to describe the proportional excess of lymphomas and gastric carcinomas among this group of individuals. It is now well-recognized that lymphomas represent one of the major life-threatening complications of natural, as well as acquired T lymphocyte immunodeficiencies (e.g. associated with chronic immunosuppressive therapy following solid organ allografting, post marrow transplant immunodeficiency, or acquired immunodeficiency syndrome, AIDS). Compared to lymphomas in presumably nonimmunodeficient persons, lymphomas in immunodeficient patients are more likely to 1) occur with higher frequency at younger ages or with short latency following initiation of immunosuppression, 2) express diffuse and high grade malignant histology, 3) develop in extranodal sites such as the central nervous syste, 4) be associated with viral transformation, particularly involving Epstein Barr virus, and 5) be unresponsive to conventional treatment modalites. In the next 24 months the ICR aims to 1) initiate studies of the etiology of lymphomas in one particular immunodeficiency, Wiskott Aldrich syndrome, 2) continue ongoing collaborations and actively solicit new collaborations which will utilize the unique resources available through the ICR, and 3) continue the development of a detailed, validated computerized data base of ICR cases as a universal resource for future studies.

自然发生的癌症患者的罕见病例收集 世界各地的免疫缺陷使研究人员能够 免疫缺陷癌症登记处 (ICR) 描述比例过量 这组个体中淋巴瘤和胃癌的发病率。 这是 现在人们普遍认为淋巴瘤是主要的疾病之一 自然和获得性 T 淋巴细胞的危及生命的并发症 免疫缺陷（例如与长期免疫抑制治疗相关） 实体器官同种异体移植后、骨髓移植后 免疫缺陷，或获得性免疫缺陷综合症，艾滋病）。 比较的 可能是非免疫缺陷者的淋巴瘤， 免疫缺陷患者更有可能 1) 发生频率更高 年龄较小或开始后潜伏期短 免疫抑制，2) 表达弥漫性和高级恶性组织学， 3) 在结外部位发育，例如中枢神经系统，4) 与病毒转化有关，特别是涉及爱泼斯坦巴尔 病毒，5) 对常规治疗方式无反应。 在 接下来 24 个月，ICR 的目标是 1) 启动病因学研究 一种特定免疫缺陷的淋巴瘤，Wiskott Aldrich 综合征，2) 继续正在进行的合作并积极寻求新的合作 它将利用 ICR 提供的独特资源，以及 3) 继续开发详细的、经过验证的计算机化数据库 ICR 案例作为未来研究的通用资源。