Transmission Electron Microscopy: Essential Support for Materials Synthesis

透射电子显微镜：材料合成的重要支持

• 批准号: EP/P030467/1
• 负责人: Chris Abell
• 金额: $ 246.21万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP030467%2F1
• 关键词: Transmission; Electron; Microscopy; Essential; Support

Advanced functional materials are fundamentally important to developing many new technologies and devices that will shape our future. They will define our ability to create cleaner, cheaper, safer and more efficient design, production, manufacturing processes, and technologies. As such, they will be instrumental in addressing many of the most pressing problems facing the world today in areas such as energy, healthcare and medicine, pollution abatement, food production, and manufacturing. Yet central to the development of these new materials is a proper understanding of the science that underpins both their structures and properties at the atomic and/or molecular level. This can only be achieved through the strategic provision of the most state-of-the-art analytical facilities.In conjunction with the Cambridge Advanced Imaging Centre (CAIC), the Chemistry Department will establish a virtual electron microscopy (EM) hub in the University that offers a unique emphasis on "materials synthesis". Capabilities will comprise bespoke facilities supporting multiple research disciplines. Spearheading this hub will be a 200 kV field emission gun-scanning transmission electron microscope (FEG-S/TEM) with excellent high resolution and STEM imaging capabilities, energy dispersive X-ray spectroscopy (EDX) and electron energy loss spectroscopy (EELS) for elucidating chemical composition and bonding, the ability to tomographically reconstruct multiple images to allow the 3D visualization of complex materials and a cryo-holder to enable the analysis not just of so-called 'hard' materials but also the study of 'soft' materials. This TEM-led hub will form one part of a University-wide EM network in which each hub maintains and develops the instrumentation for different specialties and, between them, create the necessary equipment capacity for our research portfolio across Cambridge.'Hard' materials are often highly crystalline and can exhibit long-range order; yet disorder is often critical to their function. They include metals and metal oxides, porous materials such as zeolites and metal-organic frameworks, semiconductors and ceramics. Meanwhile, 'soft' materials include self-assembled metallopolymers, polymer micelles, nano-gels and bio-inspired or biological materials. These present very different analytical challenges and mean that instruments are often designed to cope with one or other sample type. However, the latest generation of TEMs has the ability to interrogate both of these diverse types of sample. This development offers a step-change in the way that the Departments such as Chemistry, which has research groups synthesizing a broad array of hard and soft materials, can approach Advanced Materials characterization. It is now possible to develop an EM hub that caters for such a broad research demographic. This has two game-changing effects on state-of-the-art research. First, the proposed instrument will spearhead an EM hub that will offer a unique opportunity for the cross-fertilization of ideas and techniques between the hard and soft Advanced Materials communities not only in academia, but also in industry. Second, it will provide essential capacity-building to a broad range of research groups, ensuring routine hands-on access to researchers and the ability to triage samples more efficiently than is currently possible, so enhancing the effectiveness with which more detailed analysis on much more specialized instrumentation can be undertaken.The wide-ranging capabilities of the proposed Chemistry/CAIC hub mean that Advanced Materials relevant to a wide range of fields can be interrogated. We expect new data to impact on research in a range of areas, including aerospace, automotives, battery and energy technology, catering and food production, communications, drilling and refining, drug delivery, electronics, healthcare, hygiene, ICT, petrochemicals, pharmaceuticals, regenerative engineering and sensing.

先进的功能材料对于开发许多将塑造我们未来的新技术和设备至关重要。他们将定义我们创造更清洁，更便宜，更有效的设计，生产，制造过程和技术的能力。因此，他们将在能源，医疗保健和医学，消除污染，粮食生产和制造等领域中解决当今世界面临的许多最紧迫的问题。然而，这些新材料的发展的核心是对基于原子和/或分子水平上其结构和特性的科学的正确理解。这只能通过战略提供最先进的分析设施来实现。与剑桥高级成像中心（CAIC）结合使用，化学系将在大学中建立虚拟电子显微镜（EM）中心，以提供对“材料合成”的独特强调。功能将包括支持多个研究学科的定制设施。率领该枢纽将是具有出色的高分辨率和茎成像功能，能量分散X射线光谱（EDX）和电子能量损耗光谱（EELS）的200 kV场发射枪支扫描传输电子显微镜（FEG-S/TEM），并且能够赋予化学成分的能力，并允许启用多个图像的能力，并允许启用材料的能力。不仅分析了所谓的“硬”材料，还分析了“软”材料的研究。该插入式枢纽将构成大学范围内的EM网络的一部分，在该网络中，每个枢纽都维护和开发了不同专业的仪器，并在它们之间为我们的研究组合创造必要的设备能力。然而，混乱通常对他们的功能至关重要。它们包括金属和金属氧化物，多孔材料，例如沸石和金属有机框架，半导体和陶瓷。同时，“软”材料包括自组装金属聚合物，聚合物胶束，纳米凝胶和生物启发或生物材料。这些提出的分析挑战非常不同，意味着仪器通常是为应对一种或另一种样本类型而设计的。但是，最新一代的TEMS具有询问这两种不同类型的样本的能力。这一发展提供了一种逐步变化的方式，即化学等部门综合了一系列硬性和软材料的研究小组可以处理先进的材料表征。现在可以开发一个符合如此广泛的研究人群的EM枢纽。这对最先进的研究产生了两种改变游戏的影响。首先，拟议的仪器将带头一个EM枢纽，它将为硬化和软性高级材料社区之间的思想和技术交叉提供独特的机会，不仅在学术界，而且在行业中也是如此。其次，它将为广泛的研究小组提供基本的能力建设，确保与研究人员的常规动手访问以及比目前可能更有效的分类样品的能力，因此可以提高对更专业的仪器进行更详细的分析的有效性。可以进行更专业的仪器。提议的化学/CAIC HUB范围与高级材料相关的范围广泛的范围是较广泛的范围。我们预计，新数据会影响各个领域的研究，包括航空航天，汽车，电池和能源技术，餐饮和食品生产，通信，钻探和炼油，药物输送，电子，医疗保健，卫生，ICT，ICT，石化，石化，药品，药品，再生工程和感应。

项目成果

A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aß42 Aggregation.

仿生脂质模型膜对 Aä42 聚集影响的动力学图。

• DOI: 10.17863/cam.92964
• 发表时间: 2023
• 作者: Baumann K

In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe

• DOI: 10.1101/2023.07.12.548691
• 发表时间: 2023-07
• 期刊: bioRxiv
• 作者: Andrew G. Baker;H. Ou;Muhamad Hartono;A. B. Popov;Emma L. Brown;J. Joseph;Monika A Golinska;C. Sanghera;Estela González-Gualda;David Macías;Thomas R. Else;H. Greer;A. Vernet;S. Bohndiek;L. Fruk;D. Muñoz-Espín

Microwave-assisted valorization of glycerol to solketal using biomass-derived heterogeneous catalyst

使用生物质衍生的非均相催化剂将甘油微波辅助增值为缩酮醇

• DOI: 10.1016/j.fuel.2023.128190
• 发表时间: 2023
• 期刊: Fuel
• 影响因子: 7.4
• 作者: Ao S