Aluminium nitride - graphene dual-mode sensors for cancer cell detection

用于癌细胞检测的氮化铝-石墨烯双模式传感器

• 批准号: EP/P02985X/1
• 负责人: Norbert Klein
• 金额: $ 147.57万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP02985X%2F1
• 关键词: Aluminium; nitride; graphene; dual; mode

We propose to develop a technology for wafer scale device fabrication based on thin film heterostructures composed of graphene and aluminium nitride (AlN), which were recently demonstrated by our team for the first time. As a new orthogonal approach for biosensors, AlN-graphene heterostructures should enable simultaneous mass and charge detection of immobilized cellular and molecular species within one integrated device. This new capability is expected to lead to a dramatic reduction of false positives and false negatives in cancer cell detection based on antigen-antibody bond-mediated cell capturing. : As a bioactive sensor surface, bio-functionalized graphene enables charge detection via the electric field effect in graphene. Simultaneously, the graphene biointerface layer will be employed as an electrode - in combination with other graphene layer(s) embedded inside the heterostructure - to enable a fully integrated piezoelectric excitation and readout of mechanical deformations or oscillations of a free-standing AlN structure. Cell capture-induced alterations of the deformation or mechanical resonance should allow mass detection of the immobilized species. This orthogonal sensing capability of fully integrated devices will be tested and benchmarked for detection of cancer cells in blood or other body fluids.

我们建议开发一种基于石墨烯和氮化铝（ALN）组成的薄膜异质结构的晶圆刻度设备制造技术，该结构最近首次由我们的团队证明。作为生物传感器的一种新的正交方法，Aln-Graphene异质结构应同时进行质量并在一个集成装置中对固定的细胞和分子物种进行电荷检测。预计这种新能力将导致基于抗原抗体键键介导的细胞捕获的癌细胞检测中假阳性和假阴性的急剧减少。 ：作为生物活性传感器表面，生物官能化的石墨烯可通过石墨烯中的电场效应进行电荷检测。同时，将石墨烯生物界面层用作电极 - 与嵌入异质结构内部的其他石墨烯层结合使用，以实现完全集成的压电激发和读数的机械变形或自由化ALN结构的振荡。细胞捕获引起的变形或机械共振的改变应允许对固定物种进行大量检测。将测试并测试完全集成的设备的这种正交感应能力，以检测血液或其他体液中的癌细胞。

项目成果

High-resolution, spatially-resolved surface potential investigations of high-strength metallurgical graphene using scanning tunnelling potentiometry

• DOI: 10.1016/j.mee.2019.03.023
• 发表时间: 2019-05
• 期刊: Microelectronic Engineering
• 影响因子: 2.3
• 作者: K. Gajewski;P. Kunicki;A. Sierakowski;W. Szymański;W. Kaczorowski;P. Niedzielski;S. Ramadan;O. Shaforost;N. Klein;L. Hao;T. Gotszalk

Large-Area Electrodeposition of Few-Layer MoS2 on Graphene for 2D Material Heterostructures.

• DOI: 10.1021/acsami.0c14777
• 发表时间: 2020-10
• 期刊: ACS applied materials & interfaces
• 影响因子: 9.5
• 作者: Yasir J Noori;Shibin Thomas;S. Ramadan;Danielle E. Smith;V. Greenacre;N. Abdelazim;Yisong Han

Enhancing Structural Properties and Performance of Graphene-Based Devices Using Self-Assembled HMDS Monolayers.

• DOI: 10.1021/acsomega.0c05631
• 发表时间: 2021-02-23
• 期刊: ACS omega
• 影响因子: 4.1
• 作者: Ramadan S;Zhang Y;Tsang DKH;Shaforost O;Xu L;Bower R;Dunlop IE;Petrov PK;Klein N
• 通讯作者: Klein N

Detection of Glial Fibrillary Acidic Protein in Patient Plasma Using On-Chip Graphene Field-Effect Biosensors, in Comparison with ELISA and Single-Molecule Array.

• DOI: 10.1021/acssensors.1c02232
• 发表时间: 2022-01-28
• 期刊: ACS sensors
• 影响因子: 8.9
• 作者: Xu L;Ramadan S;Akingbade OE;Zhang Y;Alodan S;Graham N;Zimmerman KA;Torres E;Heslegrave A;Petrov PK;Zetterberg H;Sharp DJ;Klein N;Li B
• 通讯作者: Li B

Electronic structure influences on the formation of the solid electrolyte interphase

• DOI: 10.1039/d0ee01825b
• 发表时间: 2020-12
• 期刊: Energy & Environmental Science
• 影响因子: 32.5
• 作者: Weixin Song;Elena Stein Scholtis;P. Sherrell;D. H. K. Tsang;Jonathan Ngiam;J. Lischner;S. Fearn;V. Bemmer;C. Mattevi;N. Klein;F. Xie;D. Riley