Multi-modal Manufacturing of Medical Devices (4MD)

医疗器械多模式制造 (4MD)

基本信息

批准号：
EP/P027415/1
负责人：
Duncan Hand
金额：
$ 166.02万
依托单位：
Heriot-Watt University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FP027415%2F1
关键词：
Multi modal Manufacturing Medical Devices

项目摘要

Medical device technologies are vital for the detection and treatment of a great number of diseases and healthcare problems. Increasingly, micro-devices are being developed for minimally-invasive measurement and therapy, for example in cancer detection and drug delivery. To enable broad-based takeup of such devices it is vital to provide low-cost and reliable manufacturing solutions.The group at Heriot-Watt has significant experience in developing manufacturing solutions for a wide range of applications, with a particular focus in recent years on medical devices e.g. for cancer detection and treatment. Particular challenges include: miniaturisation to enable minimally invasive application; the low-cost integration of optical, chemical and electronic technologies; and hermetic sealing to prevent unwanted ingress of fluids, whilst allowing appropriate interaction e.g. measurement of cell stiffness, measurement of pH, laser ablation/treatment of cancerous tissue. Our manufacturing expertise (spanning laser techniques such as ablation, sintering, bonding and inscription; also additive and subtractive microfabrication processes based on mechanical, chemical, evaporative and microwave techniques), coupled with our highly supportive and growing base of clinical and industrial partners means that we are ideally placed to provide appropriate manufacturing solutions, and to enable rigorous testing and a route to commercialisation and ultimate application.The Platform will allow us to retain key staff, and to deploy them in ways that are not possible with standard proposals. In particular, we will be able to accelerate our ability to grasp immediate opportunities based on our existing collaborations, both within the group and with external partners, by carrying out critical proof-of-concept studies. The PDRAs employed will benefit greatly from the enhanced career development under the Platform. We will broaden their experience through research exchanges; engage them in proposals to win new funding; support them in applications for personal fellowships; provide them with dedicated funds for their own short proof-of-concept projects (10% of budget allocated to PDRA-led 'seedcorn' projects); provide a mentoring programme using industrial and academic members of our Advisory Board; and involve them in management of the Platform.We will organise facilitated workshops to bring together a broader group of academics and medics and to identify new collaborative activity and application areas. We will also employ targeted dissemination activity to inform current and potential industrial and clinical partners of the full range of our medical device manufacturing research activity.

医疗设备技术对于大量疾病和医疗保健问题的检测和治疗至关重要。越来越多的微型设备被开发用于微创测量和治疗，例如癌症检测和药物输送。为了使此类设备得到广泛采用，提供低成本且可靠的制造解决方案至关重要。赫瑞瓦特团队在开发适用于各种应用的制造解决方案方面拥有丰富的经验，近年来特别关注医疗设备，例如用于癌症检测和治疗。具体的挑战包括：小型化以实现微创应用；光学、化学和电子技术的低成本集成；和气密密封，以防止不必要的液体进入，同时允许适当的相互作用，例如细胞硬度测量、pH 值测量、癌组织激光消融/治疗。我们的制造专业知识（涵盖激光技术，如烧蚀、烧结、粘合和刻字；以及基于机械、化学、蒸发和微波技术的增材和减材微加工工艺），加上我们高度支持且不断增长的临床和工业合作伙伴基础，意味着：我们处于提供适当制造解决方案的理想位置，并能够进行严格的测试以及商业化和最终应用的途径。该平台将使我们能够留住关键员工，并以标准提案不可能的方式部署他们。特别是，通过开展关键的概念验证研究，我们将能够基于集团内部以及与外部合作伙伴的现有合作，加快抓住眼前机遇的能力。受聘的PDRA将大大受益于该平台下加强的职业发展。我们将通过研究交流扩大他们的经验；让他们参与赢得新资金的提案；支持他们申请个人奖学金；为他们自己的短期概念验证项目提供专用资金（分配给 PDRA 主导的“种子玉米”项目的预算的 10%）；利用我们顾问委员会的工业和学术成员提供指导计划；并让他们参与平台的管理。我们将组织研讨会，将更广泛的学者和医务人员聚集在一起，并确定新的合作活动和应用领域。我们还将采用有针对性的传播活动，向当前和潜在的工业和临床合作伙伴通报我们的全方位医疗器械制造研究活动。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Visualisation and numerical analysis of laser powder bed fusion under cross-flow

DOI：
10.1016/j.addma.2020.101690
发表时间：
2021-01-01
期刊：
ADDITIVE MANUFACTURING
影响因子：
11
作者：
Bitharas, I;Burton, A.;Moore, A. J.
通讯作者：
Moore, A. J.

Sensors for Fetal Hypoxia and Metabolic Acidosis: A Review.

DOI：
10.3390/s18082648
发表时间：
2018-08-13
期刊：
Sensors (Basel, Switzerland)
影响因子：
0
作者：
Cummins G;Kremer J;Bernassau A;Brown A;Bridle HL;Schulze H;Bachmann TT;Crichton M;Denison FC;Desmulliez MPY
通讯作者：
Desmulliez MPY

A microfluidic finger-actuated blood lysate preparation device enabled by rapid acoustofluidic mixing

DOI：
10.1101/2022.10.16.512425
发表时间：
2022-10
期刊：
bioRxiv
影响因子：
0
作者：
Md Ehtashamul Haque;A. Conde;W. Macpherson;Stephen R. Knight;R. Carter;M. Kersaudy-Kerhoas
通讯作者：
Md Ehtashamul Haque;A. Conde;W. Macpherson;Stephen R. Knight;R. Carter;M. Kersaudy-Kerhoas

A Methodology for Remote Microwave Sterilization Applicable to the Coronavirus and Other Pathogens Using Retrodirective Antenna Arrays.

DOI：
10.1109/jerm.2021.3077110
发表时间：
2022-03
期刊：
IEEE journal of electromagnetics, RF and microwaves in medicine and biology
影响因子：
0
作者：
Kossenas K;Podilchak SK;Comite D;Re PDH;Goussetis G;Pavuluri SK;Griffiths SJ;Chadwick RJ;Guo C;Bruns N;Tait-Burkard C;Haas JG;Desmulliez MPY
通讯作者：
Desmulliez MPY

Visualisation of optimisation of shielding gas coverage during gas metal arc welding

熔化极气体保护焊期间保护气体覆盖范围优化的可视化