Putting Low Coordination into Practice by the Exploration of Metal-sigma-Interactions: Fundamentals, New Catalysts and Catalysis for New Materials

通过探索金属-西格玛相互作用将低配位付诸实践：基础知识、新催化剂和新材料催化

基本信息

批准号：
EP/M024210/2
负责人：
Andrew Weller
金额：
$ 64.74万
依托单位：
University of York
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM024210%2F2
关键词：
Putting Low Coordination into Practice

项目摘要

The manipulation of chemical bonds to provide materials and chemicals of intrinsic value in the most energy and resource efficient way is at the heart of Chemistry. Catalysis is a cornerstone of this endeavour, contributing directly to the chemical industry in the UK (it is estimated that ~ 75% of all chemicals require catalysts in their manufacture), a manufacturing sector that generates ~21% of UK GDP. Transition metal-based systems play a central role in catalysis, often offering mechanistically distinct routes to molecules that could not be made by other means. The molecules thus produced may be of very high value/low volume, e.g. an intermediate in sophisticated synthetic route to a pharmaceutical; or lower relative value/high volume, e.g. polyolefins from fossil-resource derived hydrocarbons. The design, construction and implementation of new catalysts that offer step-changes in chemical manufacturing capability, in concert with improving the fundamental understanding of how chemical bonds can be manipulated, is thus central to: sustainable manufacturing, energy and resource security, and healthcare. This Fellowship will allow for the study of two highly complementary strands of catalysis discovery, development and application, that capitalise on exciting emerging results from the Weller group. The scientific aim of the Fellowship is to develop, and harness in real-world applications, the fundamental and catalytic chemistry associated with the synthesis, characterisation and utilisation of metal sigma-complexes. It is both fundamental and applied in scope, broad in its vision, and will allow for the opening up of new areas in organometallic chemistry and main-group materials chemistry. Such challenging goals would have been unreasonable until very recently, but the breakthroughs in the applicant's laboratories set the scene for these significant future developments in the field. The programme will push back the limits of what can be achieved in the synthesis of reactive organometallic compounds, their use in catalysis for the manufacture of new, and exciting, types of polymeric materials and the efficient utilisation of fossil-resource derived chemical feedstocks (alkanes) and catalysts for fine chemicals synthesis (C-H activation).

化学的核心是操纵化学键，以最有效的能源和资源方式提供具有内在价值的材料和化学品。催化是这一努力的基石，直接为英国的化学工业做出贡献（据估计，约 75% 的化学品在制造过程中需要催化剂），该制造业占英国 GDP 的约 21%。基于过渡金属的系统在催化中发挥着核心作用，通常为无法通过其他方式制备的分子提供机械上不同的途径。由此产生的分子可能具有非常高的价值/低体积，例如药物复杂合成路线中的中间体；或较低的相对价值/高产量，例如来自化石资源的碳氢化合物的聚烯烃。因此，新型催化剂的设计、构建和实施能够显着提高化学制造能力，同时提高对如何操纵化学键的基本理解，因此对于可持续制造、能源和资源安全以及医疗保健至关重要。该奖学金将允许对催化发现、开发和应用的两条高度互补的链进行研究，利用韦勒小组令人兴奋的新兴成果。该奖学金的科学目标是开发与金属西格玛配合物的合成、表征和利用相关的基础化学和催化化学，并在实际应用中加以利用。它具有基础性和应用性，视野广阔，将为有机金属化学和主族材料化学开辟新的领域。直到最近，这种具有挑战性的目标还是不合理的，但申请人实验室的突破为该领域的这些重大未来发展奠定了基础。该计划将突破反应性有机金属化合物的合成、其在催化制造新型、令人兴奋的聚合物材料中的应用以及有效利用化石资源衍生的化学原料（烷烃）的极限。）和精细化学品合成催化剂（C-H活化）。