NATURAL PRODUCT DRUGS FROM MARINE SOFT-BODIED FAUNA

来自海洋软体动物的天然药物

• 批准号: 3493317
• 负责人: JANICE L THOMPSON
• 金额: $ 5万
• 依托单位: CALBIOMARINE TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-02-22 至 1993-11-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3493317
• 关键词: animal extract; antineoplastics; drug screening /evaluation; marine biology

The goal of this project is to systematically explore the marine, soft-bodied, benthic infauna of the northeastern Pacific Ocean for antitumor and other biological activities. The following invertebrate groups will be collected: polychaetes, nemerteans, sipunculans and enteropneusts. Phase I will concentrate on collecting 10% of a program total of 200-250 species and on evaluating innovative collecting methods including vacuum extraction of sediments and selective organic enrichment of the sediment to promote recruitment and increased abundance of target species. Samples will be extracted and screened against a panel of five human tumor cell lines. Active extracts will be further fractionated according to biological activity, and described chemically. Phase II will continue this work and the NCI will be given the opportunity to screen the collection. It is expected that new chemical entities, with important pharmaceutical activities, will be described and patented; they will be licensed to the government or pharmaceutical companies for development. The evaluation of benthic marine infauna presents a new opportunity for drug discovery. Only a few infaunal species have been evaluated due to the perceived technical difficulty of collecting and recollecting infauna in kilogram quantities.

该项目的目标是系统地探索海洋、 东北太平洋的软体底栖动物群 抗肿瘤和其他生物活性。 下列无脊椎动物 将收集的群体：多毛类、纽虫类、丝虫类和 肠胃。 第一阶段将集中收集项目的 10% 总共 200-250 个物种并评估创新的采集方法 包括真空提取沉积物和选择性有机物富集 沉积物以促进招募并增加目标丰度 物种。 样本将被提取并针对五人小组进行筛选 人类肿瘤细胞系。 活性提取物将被进一步分馏 根据生物活性，并进行化学描述。 第二阶段 将继续这项工作，NCI 将有机会 筛选集合。 预计新的化学实体 重要的药物活动将被描述并获得专利；他们 将被许可给政府或制药公司 发展。 底栖海洋动物群的评估为研究提供了新的机遇 药物发现。 由于以下原因，仅对少数动物物种进行了评估 收集和回忆动物群的技术难度 以公斤为单位。