MASS SPECTROMETRIC SURFACE ANALYSIS OF MEMBRANES

膜的质谱表面分析

• 批准号: 3498797
• 负责人: Constance M John
• 金额: $ 4.99万
• 依托单位: CHARLES EVANS AND ASSOCIATES
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-15 至 1992-10-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3498797
• 关键词: chemical binding; intermolecular interaction; ionizing radiation; ions; mass spectrometry; membrane model; membrane structure; method development; surface property

DESCRIPTION (Adapted from Applicant's Abstract):The Phase I research will evaluate the feasibility of using time-of-flight secondary ion mass spectrometry (TOF-SIMS) to provide sensitive and structurally significant characterization of the surface composition of biological membranes. The research will analyze a variety of model membrane systems in order to fully evaluate this feasibility. The data produced in this study will be evaluated specifically with regard to its diagnostic value in elucidation membrane chemical structure. The long term objective of this research is to develop routine, quantitative surface analysis techniques for the chemical analysis of membrane surfaces. The achievement of this objective could find extensive application in a variety of biological sciences including synthetic membrane development, fundamental investigations of membrane structure/function relationships and possibly, better understanding of the role biomembranes play in the state of health of organisms.

描述（根据申请人的摘要改编）：第一阶段的研究将 评估使用飞行时间二级离子质量的可行性 光谱法（TOF-SIMS）提供敏感且具有结构上的显着意义 生物膜表面组成的表征。 这 研究将分析各种模型膜系统，以便完全 评估这种可行性。 这项研究中产生的数据将是 专门评估了其阐明的诊断价值 膜化学结构。 这项研究的长期目标是开发常规， 用于化学分析的定量表面分析技术 膜表面。 实现这一目标可能会发现广泛 在包括合成的各种生物科学中应用 膜开发，膜的基本研究 结构/功能关系，甚至更好地理解 生物膜在生物体健康状态中扮演角色。