EPIDEMIOLOGICAL STUDY OF ATHEROSCLEROSIS

动脉粥样硬化的流行病学研究

• 批准号: 3485208
• 负责人: CURTIS G HAMES
• 金额: $ 4.7万
• 依托单位: EVANS COUNTY HEALTH DEPARTMENT
• 依托单位国家: 美国
• 财政年份: 1972
• 资助国家: 美国
• 起止时间: 1972-08-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3485208
• 关键词: African American; United States; atherosclerosis; blood coagulation tests; cardiovascular disorder epidemiology; caucasian American; coronary disorder; diagnosis quality /standard; dietary calcium; dietary lipid; dietary potassium; disseminated intravascular coagulation; environmental health; familial hypertension; genetic models; glucose 6 phosphate dehydrogenase deficiency; health surveys; human morbidity; human mortality; hyperlipidemia; lifestyle; newborn human (0-6 weeks); nutrient intake activity; nutrition related tag; salt intake; selenium; socioenvironment; stroke; thrombosis; type A /type B personality

1. Continue the surviellance of morbidity and mortality and its correlation with known risk factors in all cohort study groups in the Evans County Studies; i.e., a) 1200 participants in NHLI lipoprotein phenotyping study-lipoprotein fractions with morbidity and mortality; b) 250 Black-White neonatal blood pressure study participants-blood pressure levels during the first year of life as a predictor of subsequent hypertension - compare Evans County neonatal Black-White blood pressure levels with comparable groups in either geographical areas; i.e., genetic vs. environmental? c) 600 stepped vs. regular care participants in the NHLI-HDFP study; d) approximately 1,900 participants of the original 1960 Evans County Study cohort; e) 1,00 oral contraceptive users vs. age, race matched non-oral contraceptive users; f) 650 Blacks and White typed for G6PD deficiency A, A(-), and B. 2. Continue to utilize the defined biracial pedigree cohorts as genetic models to study the possible inheritance of hypertension, hyperlipidemias, CHD and thrombotic proneness. 3. Maintain the study as a teaching population laboratory for the School of Public Health, Univ. of North Carolina; Duke Unversity and other institutions in which to also explore new associations between observed CHD and hypertension in the Evans County cohorts. 4. Continue to assemble and maintain all data collected or to be collected, including the frozen sera and food; make available to all qualified individuals and institutions for teaching and research. 5. Evaluate the capacity of new tests to indicate differences in intravascular coagulation between racial and social class groups as related to physical activity, social mobility and dietary deficiency. 6. Continue to study dietary sodium-potassium and calcium intake and its possible relationship to hypertension. 7. Continue to study the enigma of why the eastern coastal plains of Georgia and the Carolinas are the highest total death rate areas in the U.S. and why CHD and hypetensive-cardiovascular disease are major contributors to this mortality.

1。继续发病和死亡的生存及其相关性 在埃文斯县的所有队列研究小组中都有已知危险因素 研究；即a）NHLI脂蛋白表型的1200名参与者 研究脂蛋白的发病率和死亡率； b）250 黑白新生儿血压研究参与者血压 生命第一年的水平作为后续的预测指标 高血压 - 比较埃文斯县新生儿黑白血压 在任一个地理区域中具有可比组的水平；即遗传 与环境？ c）600阶步与常规护理参与者 NHLI-HDFP研究； d）最初的1960年约有1,900名参与者 埃文斯县研究队列； e）1,00口服避孕用户与年龄，种族 匹配的非避孕用户； f）650黑人和白色打字 G6PD缺陷A，A（ - ）和B。 2。继续利用定义的混血儿人群作为遗传 研究高血压，高脂症的可能遗传， CHD和血栓性倾斜度。 3.将研究作为学校的教学人口实验室 公共卫生，大学。北卡罗来纳州；杜克大学和其他 在其中探索观察到的CHD之间的新关联的机构 和埃文斯县队列的高血压。 4。继续组装并维护收集或收集的所有数据， 包括冷冻血清和食物；向所有合格的 个人和教学和研究机构。 5。评估新测试的能力表明差异 种族和社会阶级群体之间的血管内凝血与相关 进行体育锻炼，社会流动性和饮食不足。 6。继续研究饮食中钠钠和钙的摄入量及其 可能与高血压的关系。 7。继续研究为什么东部沿海平原的谜 佐治亚州和卡罗来纳州是最高的总死亡率区域 美国以及为什么冠心病和高hys性心血管疾病是主要的 造成这种死亡的原因。