PERIODONTITIS AND HOST DEFENSE IN JUVENILE DIABETES

青少年糖尿病中的牙周炎和宿主防御

• 批准号: 3221275
• 负责人: BYUNG H PARK
• 金额: $ 9.77万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-08-01 至 1987-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3221275
• 关键词: Actinomyces; B lymphocyte; Escherichia coli; Fusobacterium; Propionibacterium; Salmonella typhimurium; Spirochaetales; Staphylococcus aureus; Streptococcus mutans; Streptococcus sanguis; T lymphocyte; Vibrio; adolescence (12-20); anaerobic bacteria; antibacterial antibody; bacterial antigens; bactericidal immunity; cellular immunity; chemotaxis; chronic disease /disorder; complement; dental alveolus; dental disorder chemotherapy; dental disorder diagnosis; dental plaque; gender difference; gingivitis; glucose; host organism interaction; human puberty; human subject; humoral immunity; immunoglobulin A; immunoglobulin D; immunoglobulin G; immunoglobulin M; immunologic assay /test; infant human (0-1 year); inflammation; insulin; ketoacid; longitudinal human study; lymphokines; microorganism immunology; migration inhibition factor; monocyte; neutrophil; oral bacteria; osteoclast activating factor; periodontitis; phagocytosis; preventive dentistry; radiotracer; tooth resorption; urea; young adult human (21-34)

We have evaluated the periodontal conditions of about 300 patients with Juvenile Diabetes (Insulin Dependent Diabetes Mellitus, IDDM. We found that periodontitis starts at the age of 12-13 years and progressively increases to involve about 1/4 of patients 19 years or older. These periodontitis lesions characteristically started at the first molars and incisors and progressively spread to other sites. We have also found a unique constellation of bacterial flora in periodontitis in IDDM which is substantially different from those found in other forms of periodontitis. Thus, we have identified a cohort of about 300 patients with IDDM in whom the development of periodontal complication has been characterized with respect to (1) the age of onset, (2) sites of early lesions, and (3) the estimated frequency with which those lesions may develop. Such a cohort of patients with IDDM would provide an opportunity for a study of the pathogenetic mechanisms for the development of periodontitis. Our aims of this proposal are: (1) Longitudinal and prospective evaluation of periodontal conditions in a cohort of 300 patients with IDDM to document the incidence, prevalance, and progression of periodontal complications associated with IDDM, (2) Isolation and characterization of pathogenic bacteria associated with the periodontal infections in IDDM and (3) Study of the changes in microbial flora and host factors which may play a role in the development of periodontitis, whose manifestation appears to coincide with the onset of puberty in IDDM.

我们评估了约300名患有牙周病的患者的牙周状况 青少年糖尿病（胰岛素依赖性糖尿病，IDDM。我们发现 牙周炎从12-13岁开始，并逐渐发展 增加至约 1/4 的 19 岁或以上患者。 这些 牙周炎病变的特征是从第一磨牙开始 门牙并逐渐扩散到其他部位。 我们还发现了一个 IDDM 牙周炎中独特的细菌群 与其他形式的牙周炎中发现的情况有很大不同。 因此，我们确定了大约 300 名 IDDM 患者的队列，其中 牙周并发症的发展特点是 关于 (1) 发病年龄，(2) 早期病变部位，以及 (3) 估计这些病变可能发生的频率。 这样的一个队列 IDDM 患者将为研究提供机会 牙周炎发生的发病机制。 我们的目标 该建议是： (1) 纵向和前瞻性评估 记录 300 名 IDDM 患者的牙周状况 牙周并发症的发生率、患病率和进展 与 IDDM 相关，(2) 病原菌的分离和表征 与 IDDM 牙周感染相关的细菌和 (3) 研究 微生物菌群和宿主因素的变化可能在 牙周炎的发展，其表现似乎一致 随着 IDDM 青春期的开始。