IMMUNOREGULATORY ACTIVITY OF IGD

IGD 的免疫调节活性

• 批准号: 3453779
• 负责人: Richard Coico
• 金额: $ 13.27万
• 依托单位: CITY COLLEGE OF NEW YORK
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3453779
• 关键词: B lymphocyte; T lymphocyte; antibody receptor; flow cytometry; helper T lymphocyte; humoral immunity; hybridomas; immunochemistry; immunoglobulin D; immunoglobulin M; immunoregulation; laboratory mouse; tissue /cell culture

Injections of IgD-containing ascites or purified IgD into BALB/c mice cause enhancement of antibody production to trinitrophenylated (TNP) conjugates. Splenic T cells from IgD pretreated mice transfer this enhanced ability to produce antibody to normal recipients. Experiments are proposed to characterize the cells response for this effect and to analyze the regulatory events involved in this phenomenon at the molecular level. The suggested approach is based on the working hypothesis that T cells with Fc receptors for IgD down-regulate IgD transcription and simultaneously stimulate IgM secretion and/or secretion of other Ig isotypes.

注射含IgD的腹水或纯化的IgD导致BALB/C小鼠引起 增强对三硝基苯基化（TNP）结合物的抗体产生。 来自IGD预处理小鼠的脾T细胞转移了这种增强的能力 与普通接受者产生抗体。 提出了实验 表征细胞响应的这种作用，并分析 该现象在分子水平上涉及的调节事件。 这 建议的方法基于以下假设：T细胞具有FC IgD的受体下调IgD转录，并同时进行 刺激其他Ig同型的IgM分泌和/或分泌。