STATISTICAL ANALYSIS OF PEDIATRIC TASK FORCE DATA BASE

儿科工作组数据库统计分析

• 批准号: 3426803
• 负责人: Bernard A Rosner
• 金额: $ 8.98万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1994-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3426803
• 关键词: African American; Hispanic Americans; adolescence (12-20); age difference; blood pressure; body composition; body height; body physical characteristic; body weight; cardiovascular disorder epidemiology; caucasian American; child (0-11); female; gender difference; human subject; male; racial /ethnic difference; statistics /biometry

Hypertension is a well-recognized risk factor for cardiovascular disease in adults. Furthermore, many studies have shown that there is tracking among longitudinal pediatric blood pressure determinations. An important unresolved goal in pediatric hypertension research is to define at what level of pediatric blood pressure is a child at increased risk for adult hypertension. There have been two NHLBI Task Forces in Blood Pressure Control in Children which have published reports in 1977 and 1987. One of the goals of each task force has been to define appropriate percentiles for blood pressure in children. In the Second Task Force Report, results from nine large epidemiologic studies were combined into a data base with more than 70,000 readings from which blood pressure percentiles were derived as a function of age and sex. However, many research workers have stated that height is more strongly related to blood pressure than age and have urged that Normative data for pediatric blood pressure be demarcated by height rather than age. An important goal of this application is to define sex-specific blood pressure percentiles that are a function of both age and height. Another unresolved issue in hypertension research is to define the precise age at which blood pressure distributions for different racial groups diverge. This is one of the few data bases that can address this issue since we have readings from over 43,000 white children, 23,000 black children, and 4,500 hispanic children. This will be a more than adequate sample size to test this hypothesis. If differences are found, than it is of great interest to estimate the earliest age at which racial differences in blood pressure are apparent. In summary, the previous Pediatric Task Force reports have been limited in the scope of data presented, mainly due to space limitations. We will construct blood pressure percentiles that are a function of age, sex, race, and height, which should provide a more comprehensive profile of pediatric blood pressure distributions than any previously published work.

高血压是心血管疾病的公认危险因素 在成年人中。此外，许多研究表明有跟踪 在纵向小儿血压测定中。一个重要的 小儿高血压研究中未解决的目标是定义什么 小儿血压水平是成人风险增加的孩子 高血压。血压中有两个NHLBI工作队 1977年和1987年发表报告的儿童的控制。 每个工作组的目标是定义适当的百分位数 儿童的血压。在第二个工作队报告中，结果 将九个大型流行病学研究合并为数据库 超过70,000个读数，从中得出血压百分位数为 年龄和性别的功能。但是，许多研究工作者表示 高度与血压更密切相比，并且敦促 小儿血压的规范数据被高度划分 而不是年龄。该应用程序的重要目标是定义 性别特异性的血压百分位数是年龄和年龄的函数 高度。 高血压研究中的另一个尚未解决的问题是定义确切的问题 年龄在哪个不同种族组的血压分布 分歧。这是可以解决此问题的少数数据库之一 由于我们有超过43,000名白人儿童的读物，23,000个黑色 孩子和4,500名西班牙裔孩子。这将是足够的 样本大小以检验该假设。如果发现差异，则 非常有趣的估计种族差异的最早年龄 在血压中是显而易见的。 总而言之，先前的儿科工作队报告受到限制 显示的数据范围主要是由于空间限制。我们将 构建血压百分位数，这是年龄，性别，种族的函数 和高度，这应该提供儿科的更全面的特征 血压分布比任何先前发表的工作。