PERIMETRIC RESULTS IN THE OPTIC NEURITIS TREATMENT TRIAL

视神经炎治疗试验的视野检查结果

• 批准号: 3426655
• 负责人: CHRIS A JOHNSON
• 金额: $ 6.63万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1994-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3426655
• 关键词: automated data processing; information systems; longitudinal human study; method development; optic neuritis; perimetry; prognosis; vision disorders; vision tests; visual fields; visual perception

Optic neuritis is a common optic nerve disorder usually affecting individuals between the ages of 15 and 45. The pathogenesis is related to demyelination regardless of whether or not multiple sclerosis is present. Because there were no established guidelines to follow in deciding upon a treatment for a patient with this condition, the Optic Neuritis Treatment Trial (ONTT) was initiated. The ONTT protocol was designed to determine the value of corticosteroids in the treatment of optic neuritis. Two primary outcome measures, contrast sensitivity and visual field sensitivity, and two secondary outcome measures, color discrimination and visual acuity, were utilized to assess treatment efficacy. The major objective of this research project is to conduct a detailed analysis of visual field data from the ONTT. Although visual field information was used as an outcome measure in the ONTT study, only general summary values were examined. This project will incorporate a thorough evaluation of visual field data from the ONTT that is directed to four primary issues: (1) Determine the relationship of specific patterns of visual field loss to final visual outcome, recurrences of visual loss and treatment. (2) Quantitatively characterize the loss and recovery of visual field sensitivity in optic neuritis. (3) Evaluate the interrelationships among patient response characteristics, test conditions and visual field results. (4) Compare existing visual field analysis procedures and develop new methods of quantitatively evaluating and characterizing visual field loss. The visual field database for the ONTT provides a unique opportunity to evaluate visual field loss in optic neuritis. The use of stringent test protocols, the standardization of equipment and test procedures, the training and certification of visual field technicians, the quality control assessment of all visual field examinations, the high compliance of patients in meeting their scheduled appointments, and the automated data conversion and processing procedures all ensure that the ONTT visual field database is of higher quality than any previous multi-center study. These factors, in conjunction with the size of the patient population, the large number of. visual field examinations per patient, and the high compliance for scheduled followup visits make it possible to conduct a detailed examination of visual field properties in optic neuritis, determine the prognostic value of specific visual field characteristics, and evaluate the possibility of additional differences in visual field properties among treatment groups. In addition, the variety of visual field deficits that are present in optic neuritis makes the ONTT database an ideal resource for developing and evaluating different quantitative visual field analysis procedures.

视神经炎是一种常见的视神经障碍，通常会影响 15至45岁之间的个体。发病机理是相关的 无论多发性硬化症是否是脱髓的 展示。 因为没有既定的准则要遵循 决定为患有这种疾病的患者进行治疗 启动了神经炎治疗试验（ONTT）。 ONTT协议是 旨在确定皮质类固醇在处理中的价值 视神经炎。 两种主要结果指标，对比灵敏度和 视野灵敏度和两个次要结果指标，颜色 歧视和视力被用于评估治疗 功效。 该研究项目的主要目的是进行详细的 来自ONTT的视野数据的分析。 虽然视野 信息在ONTT研究中被用作结果指标 检查了一般摘要值。 这个项目将包含一个 对定向的ONTT的视野数据进行彻底评估 到四个主要问题：（1）确定特定的关系 视野丢失到最终视觉结果的模式，复发 视觉丧失和治疗。 （2）定量表征损失和 恢复视野神经炎中的视野灵敏度。 （3）评估 患者反应特征之间的相互关系，测试 条件和视野结果。 （4）比较现有的视野 分析程序并开发新的定量评估方法 并表征视野损失。 ONTT的视野数据库提供了一个独特的机会 评估视野神经炎的视野损失。 严格测试的使用 协议，设备和测试程序的标准化， 培训和认证视野技术人员，质量 所有视野考试的控制评估，高依从性 在确定预约和自动化的患者中 数据转换和处理过程都确保了ONTT Visual 现场数据库的质量高于任何以前的多中心研究。 这些因素与患者人群的大小结合 大量。每个患者的视野检查和高 预定后续访问的合规性使得 详细检查视野神经炎的视野特性， 确定特定视野特征的预后价值， 并评估视野其他差异的可能性 治疗组之间的特性。 另外，视觉的种类 视神经炎中存在的现场缺陷使ONTT数据库 开发和评估不同定量的理想资源 视野分析程序。