How do unconventional T cells die?

非常规T细胞如何死亡？

• 批准号: DP240101173
• 负责人: A/Prof Alexandra Corbett
• 金额: $ 44.93万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101173
• 关键词: How; do; unconventional; cells; die

Mammalian cells die via several different mechanisms, each of which is tightly controlled at a molecular level. The choice of death pathway depends on the trigger and cell type. This project will investigate the mechanisms controlling death of T cells, including conventional T cells, and unconventional T cells, such as mucosal-associated invariant T (MAIT) cells, in normal conditions and during inflammation. It combines methods we developed to study MAIT cells in vivo with expertise in cell death analysis. This project is expected to elucidate the complex mechanisms controlling T cell survival/death and increase our fundamental understanding of cell death mechanisms of activated T cells.

哺乳动物细胞通过几种不同的机制死亡，每种机制都在分子水平上紧密控制。死亡途径的选择取决于触发因素和细胞类型。该项目将研究控制T细胞死亡的机制，包括常规T细胞以及在正常情况下和炎症期间，包括常规T细胞和非常规的T细胞，例如与粘膜相关的不变T（MAIT）细胞（MAIT）细胞。它结合了我们开发的方法来研究体内MAIT细胞和细胞死亡分析方面的专业知识。预计该项目将阐明控制T细胞存活/死亡的复杂机制，并增加我们对活化T细胞细胞死亡机制的基本理解。