GASTRIC FUNCTION--CENTRAL CONTROL

胃功能——中枢控制

• 批准号: 3409219
• 负责人: Richard C. Rogers
• 金额: $ 9.75万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3409219
• 关键词: calcitonin; cerebellar cortex; electrophysiology; electrostimulus; gastric acid; gastrins; gastrointestinal function; gastrointestinal pharmacology; hormone inhibitor; hypothalamus; limbic system; microelectrodes; microinjections; neural information processing; neurophysiology; neurotensin; peptic ulcer; prosencephalon; sensorimotor system; somatostatin; stomach motility /pressure; stress

The proposed project is designed to provide insight into the neurophysiological relationships between hypothalamic and limbic activity and vagal control over gastric function which are important to an understanding, and eventual management, of stress-induced gastric pathology. It addresses recent findings which indicate that messenger peptides localized in the pre-vagal forebrain nuclei (paraventricular neuleus of the hypothalamus (PVN); bed nucleus of the stria terminalis (BNST); and the central nucleus of the amygdala (CNA) and medullary vagal neurons either exacerbate or suppress the development of stress-induced gastric ulcers. The overall objective of this project is to determine whether neuropeptides which profoundly affect gastrointestinal function, when injected into the brain, do so by acting within a system of forebrain neurons connected directly with second-order neurons in sensory pathways from the stomach and the medullary neurons that project to the stomach. Specifically, the effects of neural activity in the PVN, CNA, and BNST on gastric vagal neurons will be examind using electrical or glutamate microstimulation in conjunction with electro-physiological recording and spike-triggered averaging techniques. Peptides known to be localized within these hypothalamic nuclei, as well as antagonists, will be microinjected into the brain. We will evaluate the peptidergic receptors involved in the hypothalamo-vagal pathway. Gastric motor function will be monitored with extraluminal strain gauges or gastric acid secretion will be measured in order to determine the effect of central nervous system manipulations.

拟议的项目旨在提供对 下丘脑与神经生理学之间的关系 边缘系统活动和迷走神经对胃功能的控制 对于理解和最终管理很重要 应激诱发的胃病理学。 它解决了最近的发现 这表明信使肽定位于 迷走神经前脑核（室旁核） 下丘脑（PVN）；终纹床核（BNST）； 以及杏仁核 (CNA) 和延髓的中央核 迷走神经元要么加剧要么抑制发展 压力引起的胃溃疡。 本次活动的总体目标 该项目的目的是确定神经肽是否对 注射到大脑后会影响胃肠功能， 通过在连接的前脑神经元系统内起作用来实现这一点 直接与来自感觉通路的二阶神经元 胃和投射到胃的髓质神经元。 具体来说，PVN、CNA 中神经活动的影响， 和 BNST 对胃迷走神经元的影响将使用 电或谷氨酸微刺激结合 电生理记录和尖峰触发平均 技术。 已知位于这些内的肽 下丘脑核团以及拮抗剂将 显微注射到大脑中。 我们将评估肽能 参与下丘脑-迷走神经通路的受体。 胃 运动功能将通过腔外应变进行监测 将测量压力表或胃酸分泌量，以便 确定中枢神经系统操作的效果。