PERIPHERAL NERVE REGENERATION AND DORSAL HORN SOMATOTOPY

周围神经再生和背角体型

• 批准号: 3407538
• 负责人: H Richard Koerber
• 金额: $ 14.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3407538
• 关键词: afferent nerve; cats; dorsal column; electron microscopy; electrophysiology; histology; innervation; nervous system regeneration; neural information processing; neural plasticity; neural transmission; peripheral nervous system; receptor; single cell analysis; somesthetic sensory cortex; spinal nerves; synapses

Reinnervation of peripheral receptors following peripheral nerve lesions results in a variety of sensory deficits. These include a decrease in general sensory acuity and the loss of the ability to correctly localize peripheral stimuli. Other common symptoms include several hypersensitivity reactions such as, Hyperesthesia, Dysesthesia, Hyperalgesia and Causalgia which can be very disabling to individuals. Although some of these deficits can be permanent, others can be reversed following reinnervation of peripheral receptors. Recent studies in primates have demonstrated that reinnervation following peripheral nerve transection elicits organizational changes in the somatosensory cortex. It has been suggested that these organizational changes may parallel in some manner the clinically observed recovery from sensory deficits following these lesions. The long term objective of this project is to assess the contributions of the regenerative process and possible changes in subcortical structures, specifically the spinal dorsal horn, to these changes. Newly developed single fiber recording and stimulation procedures will be employed to examine: 1) how specific sensory inputs from individual characterized primary sensory afferents are processed by both the population of dorsal horn cells receiving input from single fibers and by individual identified dorsal horn neurons; 2) the specificity of the regenerative process (e.g. do regenerating fibers reinnervate the same type of receptor they had originally innervated?); 3) the affect of reinnervation on the central processing of these identified inputs during the recovery period. This information will allow the identification of those processes which can contribute to the recovery seen after disruption of sensory inputs. Once identified, these processes can then be studied further to determine if certain manipulations could enhance their efficacy.

周围神经病变后周围受体的重新连接 导致各种感觉缺陷。这些包括减少 一般的感觉敏锐度和正确定位能力的丧失 外围刺激。其他常见症状包括多种超敏反应 反应，例如感觉障碍，心觉，痛觉过敏和因果关系 这可能是对个人的残疾。尽管其中一些缺陷 可以是永久的，在加剧之后，其他人可以逆转 外围受体。关于灵长类动物的最新研究表明 外围神经横向后的重新支配会引起组织 体感皮质的变化。有人建议这些 组织变化可能以某种方式平行于临床观察 这些病变后的感觉缺陷恢复。 该项目的长期目标是评估 再生过程和皮层结构的可能变化， 特别是脊柱背角，要进行这些变化。新开发 单纤维记录和刺激程序将采用 检查：1）来自个人表征的特定感觉输入如何 主要的感官传入均由背面的两个种群处理 喇叭单元从单纤维接收输入，并通过个人识别 背角神经元； 2）再生过程的特异性（例如 再生纤维是否会加剧与它们具有相同类型的受体 最初支配了？）; 3）重新支配对中央的影响 在恢复期间处理这些已识别的输入。 这些信息将允许识别那些可以 有助于在感觉输入中断后看到的恢复。一次 确定，可以进一步研究这些过程，以确定是否是否 某些操纵可以增强其功效。