BONE DENSITY CHANGES IN SPINAL-CORD INJURED PATIENTS

脊髓损伤患者的骨密度变化

• 批准号: 3160551
• 负责人: THOMAS N. HANGARTNER
• 金额: $ 29.28万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-25 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3160551
• 关键词: bone density; bone disuse atrophy; clinical biomedical equipment; computed axial tomography; electrostimulus; exercise; human subject; mechanical stress; muscle contraction; paralysis; radiography; rehabilitation; spinal cord injury

DESCRIPTION: (Adapted from investigator's abstract) The proposed project will document bone loss in the legs of spinal-cord injured patients, using a sample of 20 individuals with recent spinal-cord injury. The research will evaluate the pattern of bone loss over a 2-year period, after injury. Specifically, the onset of bone loss and the rate of loss will be analyzed. In addition to individual and group comparison over time, the amount of bone loss will be compared to some bone-specific markers. This research should yield information important to the well-being of paralyzed individuals, in addition to data of broader significance and applicability. Precise knowledge of bone-loss rates and patterns (up to .5% precision) will aid in decisions about patient suitability for walking experiments, now becoming more prevalent with advances in the field of functional electrical stimulation. It will also provide a basis for the development of treatment methods for bone loss, either for paralyzed individuals or those who are confined to bed for long periods of time. Finally, the spinal-cord injured patient serves as a model to study the effects of weightlessness in space flight, permitting estimation of maximal duration of space travel without long-term bone loss.

描述：（改编自研究者的摘要）拟议的项目 将记录脊髓损伤患者腿部的骨质流失，使用 20 名近期脊髓损伤患者的样本。 研究 将评估受伤后两年内的骨质流失模式。 具体来说，将分析骨质流失的发生和流失率。 除了随着时间的推移进行个人和群体比较之外， 骨质流失将与一些骨特异性标记物进行比较。 这项研究 应产生对瘫痪者的福祉重要的信息 个人，以及具有更广泛意义和适用性的数据。 准确了解骨质流失率和模式（精度高达 0.5%） 将有助于决定患者是否适合步行实验， 随着功能领域的进步，现在变得更加普遍 电刺激。 也将为发展提供基础 骨质流失的治疗方法，无论是针对瘫痪个体还是 那些长时间卧床不起的人。 最后， 脊髓损伤患者作为研究模型 太空飞行中的失重状态，允许估计最大持续时间 太空旅行而不会出现长期骨质流失。