AFFERENT INFLUENCES ON NERVOUS SYSTEM DEVELOPMENT

传入对神经系统发育的影响

• 批准号: 3395998
• 负责人: THOMAS N PARKS
• 金额: $ 10.29万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-03-01 至 1988-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3395998
• 关键词: afferent nerve; animal developmental psychology; auditory deprivation; auditory nuclei; auditory pathways; brain stem; electron microscopy; hearing disorders; histology; infant animal; mammalian embryology; microscopy; neuroanatomy; neurons; silver impregnation; synapses

The study of how afferent synaptic connections and activity influence neuronal development is central to further understanding of both neuroembryology and of the manner in which early sensory experience influences brain and behavior development. The proposed experiments will examine with light and electron microscopic methods the morphological organization and development of two avian brain stem auditory nuclei: nucleus magnocellularis and nucleus laminaris. The normal ontogeny of these neurons will be contrasted with their development after embryonic deafferentation or early restriction of the acoustic environment. This work will bring together manipulations of morphological and experiential variables in order to examine a wide range of afferent influences in the early life of two functionally-related neuronal types with many advantages for such studies. A major objective is to provide neuropathologic information on the central neural affects accompanying early acoustic deprivation or receptor damage. Several of the proposed experiments will involve early manipulations of the middle and inner ears, with subsequent study of morphological development in second-order and third-order auditory neurons in the brain. This project will provide a detailed and comprehensive survey of the effects on auditory neuron development of early conductive and sensorineural hearing loss.

关于传入突触连接和活动如何影响的研究 神经元发展对于进一步理解两者至关重要 神经生物学和早期感觉体验的方式 影响大脑和行为发展。 提出的实验将 使用光和电子显微镜方法检查形态学 两个禽脑干听觉核的组织和发展： 核细胞核和层核。 正常的个体发育 这些神经元将与胚胎后的发育形成鲜明对比 声音环境的停用或早期限制。 这 工作将汇集形态和体验的操纵 变量为了检查广泛的传入影响 具有许多优势的两种与功能相关的神经元类型的早期生活 进行此类研究。 一个主要目标是提供神经病理学 关于早期声学的中央神经影响的信息 剥夺或受体损害。 提出的一些实验将 涉及中部和内耳的早期操纵，随后 研究二阶和三阶听觉中形态发展的研究 大脑中的神经元。 该项目将提供详细的 全面调查对早期听觉神经元发展的影响 导电和感觉性听力损失。