Biocompatible Polymer Colloids for Bionanotechnology Applications

用于生物纳米技术应用的生物相容性聚合物胶体

基本信息

批准号：
EP/J007846/1
负责人：
Steven Armes
金额：
$ 131.3万
依托单位：
University of Sheffield
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FJ007846%2F1
关键词：
Biocompatible Polymer Colloids Bionanotechnology Applications

项目摘要

The three principal scientists in this research programme have highly complementary expertise. Prof. Armes is a synthetic polymer chemist, which means that he designs and makes long-chain molecules. Prof. Ryan is a polymeric materials scientist; his interests lie in the structure and properties of polymers, particularly on the nanometre length scale. Prof. Battaglia is a bio-engineer, who uses his quantitative background to bring academic rigour to the biological sciences. In the last few years, we have worked together (often as pairs, sometimes as a group of three) to conduct numerous inter-disciplinary scientific studies at Sheffield University. This collaborative approach allows us to tackle important scientific problems and questions that we could not contemplate addressing as individual investigators. This Platform Grant will provide us with the opportunity to formalise this ethos and to build a world-class close-knit team over the medium term. Our vision is to conduct transformative research in the area of polymer-based bionanotechnology, which we define as the application of synthetic polymers (man-made long-chain molecules) to solve important biological problems.This proposal is underpinned by an important breakthrough in the design of bespoke organic nanoparticles recently made by Prof. Armes. His team has developed a robust, patented formulation that enables the efficient synthesis of biocompatible nanoparticles possessing spherical, worm-like or vesicular (i.e. hollow particles) morphologies directly in water using readily available starting materials. We are currently learning the design rules to reliably predict the final particle morphology, which is transforming our understanding compared to the previous ad hoc syntheses described in the literature. This new insight will provide us with an unprecedented opportunity to explore various biomedical applications, including enhanced live cell imaging, thermo-responsive gels for cell culture studies and the efficient delivery of antibodies into cells. Our work will involve the integration of innovative polymer chemistry, state-of-the-art characterisation techniques and world-class bio-engineering to produce a paradigm shift in the fast-moving inter-disciplinary field of bionanotechnology.We intend to interact fruitfully with an informal network of six named internationally-renowned scientists to access their expertise and instrumentation and hence extract maximum scientific value from this Platform grant. Our post-doctoral scientists will be offered the opportunity to spend up to three months on secondment with our collaborators learning new techniques, experiencing other scientific cultures and enhancing their skill sets. Finally, in addition to our ambitious scientific programme, we intend to provide inspirational leadership and active mentoring for our excellent post-doctoral scientists to enable them to attain their long-term career goals.All three principal scientists have worked extensively with industrial companies, ranging from the world's largest chemical company (BASF) to a single employee SME. Current sponsors include: P & G, Cytec, Biocompatibles, Reckitt Benckiser, Unilever, AkzoNobel, Croda, Scott Bader, SSL and Vivacta. Thus each Investigator is 'outward-facing' regarding the potential commercial impact of our work and is well aware of the value of IP protection (all are named inventors on multiple patent applications). Thus our team is both well-placed and has the appropriate contacts with various named companies (see case for support) to ensure that any new intellectual property resulting from this project will be fully exploited. Moreover, we have also been active in various outreach activities to communicate our findings to the general public. This is essential to assure the UK tax-payer of the importance of maintaining a long-term strategic investment in scientific research conducted in UK Universities.

该研究计划中的三位主要科学家具有高度互补的专业知识。 Armes教授是一位合成聚合物化学家，这意味着他设计并制造了长链分子。瑞安教授是一位聚合物材料科学家。他的兴趣在于聚合物的结构和特性，尤其是在纳米长度尺度上。 Battaglia教授是一位生物工程师，他利用其定量背景为生物科学带来了严格的学术性。在过去的几年中，我们共同努力（通常是成对，有时是三人一组），在谢菲尔德大学进行了众多跨学科的科学研究。这种协作方法使我们能够解决我们无法作为个人调查人员致辞的重要科学问题和问题。该平台赠款将为我们提供正式化这种精神并在中期建立世界一流的紧密联系团队的机会。我们的视野是在基于聚合物的生物植物学领域进行变革性研究，我们将其定义为合成聚合物（人造的长链分子）以解决重要的生物学问题的应用。该提案是由Prof Prof Prof Prof.Armes制造的重要突破性的基础。他的团队开发了一种强大的专利配方，可以有效地合成具有球形，类似蠕虫的或囊泡（即空心颗粒）形态的生物相容性纳米颗粒，并使用易于可用的起始材料直接在水中。我们目前正在学习设计规则，以可靠地预测最终的粒子形态，这与文献中描述的先前的临时合成相比，我们正在改变我们的理解。这种新的见解将为我们提供前所未有的机会，以探索各种生物医学应用，包括增强的活细胞成像，用于细胞培养研究的热响应性凝胶以及有效地将抗体传递到细胞中。我们的工作将涉及创新的聚合物化学，最先进的特征技术和世界一流的生物工程技术的整合，以在快速发展的Bionanotechnology的快速发展的跨学科领域进行范式转移。我们打算与六个名为“统治者”的非正式网络依次访问其专业化和HENCESTICARICION和HENCERIDIAD EXTICATION和HENCESICTION和HENCERICY cORTICTICARICION和HENCERICY cOLTICTICARICION和HENCERICY INTERCTICATION和HENCERICY INTERCATION。我们的博士后科学家将有机会与我们的合作者一起学习新技术，体验其他科学文化并增强其技能。最后，除了我们雄心勃勃的科学计划外，我们还打算为我们出色的博士后科学家提供鼓舞人心的领导力和积极指导，以使他们能够实现其长期职业目标。所有三位主要科学家都与工业公司广泛合作，从世界上最大的化学公司（BASF）到单个员工SME。当前的赞助商包括：P＆G，Cytec，BioPompatibles，Reckitt Benckiser，Unilever，Akzonobel，Croda，Scott Bader，SSL和Vivacta。因此，每个研究人员都对我们作品的潜在商业影响“面向”，并且非常意识到IP保护的价值（所有这些都命名为发明家在多个专利申请中）。因此，我们的团队既有位置良好，又与各种命名公司（请参阅支持案）具有适当的联系，以确保该项目产生的任何新知识产权都将得到充分利用。此外，我们还积极从事各种外展活动，将我们的发现传达给公众。这对于确保英国税收者保持对英国大学进行的科学研究的长期战略投资的重要性至关重要。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

pH-Responsive Schizophrenic Diblock Copolymers Prepared by Polymerization-Induced Self-Assembly.

DOI：
10.1021/acs.macromol.7b01005
发表时间：
2017-08-22
期刊：
Macromolecules
影响因子：
5.5
作者：
Canning SL;Neal TJ;Armes SP
通讯作者：
Armes SP

Phenyl acrylate is a versatile monomer for the synthesis of acrylic diblock copolymer nano-objects via polymerization-induced self-assembly

DOI：
10.1039/c7py01161j
发表时间：
2017-09-07
期刊：
POLYMER CHEMISTRY
影响因子：
4.6
作者：
Canning, S. L.;Cunningham, V. J.;Armes, S. P.
通讯作者：
Armes, S. P.

New poly(amino acid methacrylate) brush supports the formation of well-defined lipid membranes.

DOI：
10.1021/la504163s
发表时间：
2015-03-31
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
0
作者：
Blakeston AC;Alswieleh AM;Heath GR;Roth JS;Bao P;Cheng N;Armes SP;Leggett GJ;Bushby RJ;Evans SD
通讯作者：
Evans SD

Determining the Effective Density and Stabilizer Layer Thickness of Sterically Stabilized Nanoparticles.