Modular Helicenoid Lewis Base Catalysts Applied to Modern Synthesis and Materials

模块化螺烯路易斯碱催化剂应用于现代合成和材料

• 批准号: EP/J005118/1
• 负责人: David Carbery
• 金额: $ 54.66万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ005118%2F1
• 关键词: Modular; Helicenoid; Lewis; Base; Catalysts

The property of handedness is of extreme importance in chemistry because this property controls so many aspects of life, both inside ourselves and the world around ourselves. The shapes of molecules act in a similar fashion to the human hand: you will struggle to properly fit a left hand into a right handed glove. This handedness of molecules has profound effects on their biological activity. Therefore, being able to control the handedness of synthesised compounds is critical to the function of these products. One way to accomplish this is by using catalysts that possess one-sense of handedness. An area of increasing relevance to chemistry, and society beyond the world of chemical research, is organocatalysis where small organic molecules, as opposed to transition metals, catalyse the formation of useful handed molecules.Nature constructs many structures which are based upon a helical shape, from the large (e.g. hurricanes) to the very small (our genetic DNA). These structures are chiral by virtue of being helical, that is, they are "handed." This proposal concerns the development of much improved, powerful helical organic catalysts. We wish to use these to control the handedness when forming products with a specific sense of handedness or when performing polymerisations. This project will examine the development of new reactions and the formation of "handed" polymers, with progress in these areas likely to be of significant benefit to science and society.In particular, the polymers we wish to examine may have a large impact on all of our lives. We will seek to use our catalysts to make polymers, made from materials sourced from almonds, which will have properties similar to polystyrene. This has significance as polystyrene is a non-biodegradable material filling global land fill sites. We all see a lot of polystyrene on a day-to-day basis... the mountain of "coffee cups" rises and rises in land fill contexts. The polymers we will synthesise will be biodegradable, so will compost quite happily yet our catalyst will help us keep the desirable mechanical properties of polystyrene.Taken together, this project will make strides in new catalyst design, reaction development and searching for new "green" polymers to replace an evasive, taken for granted polymer.

惯用性在化学中至关重要，因为这种财产控制着生活的许多方面，无论是在我们自己和周围的世界内部。分子的形状与人的手相似：您将难以正确地将左手放入右手手套中。这种分子的手法对其生物学活性具有深远的影响。因此，能够控制合成化合物的惯用性对于这些产品的功能至关重要。实现此目的的一种方法是使用具有一体义的催化剂。与化学研究世界之外的社会相关的领域是有机催化的，其中小有机分子与过渡金属相反，催化了有用的手工分子的形成。从大型（例如，飓风）到小（我们的属性），基于螺旋形状的许多结构。这些结构是手性的，因为它们是“交接”的。该提案涉及改进，强大的螺旋有机催化剂的发展。我们希望使用它们以特定的触觉或执行聚合时的形成产品时，可以使用它们来控制惯用性。该项目将研究新反应的发展和形成“授予”的聚合物，在这些领域的进步可能会对科学和社会带来重大好处。尤其是，我们希望检查的聚合物可能会对我们的一生产生重大影响。我们将寻求使用催化剂制造由杏仁采购的材料制成的聚合物，该材料具有类似于聚苯乙烯的特性。这具有重要意义，因为聚苯乙烯是一种不可生物降解的材料，填充全球填充地点。我们每个人每天都看到很多聚苯乙烯...“咖啡杯”的山上上升，在陆地填充环境中上升。我们将合成的聚合物将是可生物降解的，因此堆肥将非常幸福，但是我们的催化剂将帮助我们保持聚苯乙烯的理想机械性能。