Combinatorial design of multivalent polymers for cell receptor clustering

用于细胞受体聚集的多价聚合物的组合设计

• 批准号: DE170100315
• 负责人: Dr Robert Chapman
• 金额: $ 25.19万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100315
• 关键词: Combinatorial; design; multivalent; polymers; cell

This project aims to design biologically active multivalent peptide-polymer conjugates. This project will use an enzyme to conduct the reactions in tiny volumes in the open air, and prepare and screen large libraries of different architectures for their ability to kill cancer cell lines through the clustering of death receptor proteins on the cell surface. Such combinatorial techniques have been crucial to the development of small molecule drugs. This project aims to apply this technique to well-defined macromolecules, studying their structure-activity relationships, and could lead ultimately to the generation of lead compounds for therapeutics with high commercial relevance.

该项目旨在设计具有生物活性的多价肽-聚合物缀合物。该项目将使用一种酶在露天进行微小体积的反应，并准备和筛选不同结构的大型文库，以确定它们通过细胞表面死亡受体蛋白的聚集来杀死癌细胞系的能力。这种组合技术对于小分子药物的开发至关重要。该项目旨在将该技术应用于明确的大分子，研究它们的结构-活性关系，并最终可能导致产生具有高度商业相关性的治疗药物的先导化合物。