NEUROTROPIC DRUGS, HORMONES AND BRAIN FUNCTION

神经营养药物、激素和脑功能

• 批准号: 3374629
• 负责人: SAUL M SCHANBERG
• 金额: $ 35万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-09-01 至 1993-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3374629
• 关键词: adrenocorticotropic hormone; animal developmental psychology; brain metabolism; corticosterone; deoxyglucose; drug metabolism; endorphins; enzyme inhibitors; growth /development; hormone regulation /control mechanism; infant animal; insulin; laboratory rat; lung; mother deprivation; neural information processing; neuroendocrine system; neuropharmacologic agent; neurotransmitter metabolism; neurotransmitters; ornithine; ornithine decarboxylase; radiotracer; serotonin; somatotropin; stress

We propose to investigate the interrelationships of various hormones neuropeptides and neurotransmitters to metabolic state and the normal development of brain and other vital organs and to study the mechanisms by which these neurochemicals mediate the perturbations in growth, development and metabolism resulting from "maternal deprivation". Our aim is to elucidate the role that the CNS plays in the control of early development through the regulation of neurochemical release and cell metabolism and identify the brain regions involved in mediating the effects of these neurochemicals and environmental influences on vital organ growth and function in normal and abnormal states. The basic experimental approach utilizes assessment of multiple physiological and biochemical parameters in developing organs primarily brain, lung, heart and liver as indices of altered functional maturation of these tissues directly resulting from specific sensory or nutritional conditions innate to the maternal deprivation paradigm. Principal systems analyzed in these studies include metabolic (polyamine and glucose) endocrine (GH insulin, and glucocorticoid, i.e., CRF, ACTH, corticosterone) and neurotransmitter (serotonin, catecholamine, endorphin and opiate).

我们建议调查各种相互关系 激素神经肽和神经递质到代谢状态 以及大脑和其他重要器官的正常发展以及 研究这些神经化学物质介导的机制 导致增长，发展和代谢的扰动 从“孕产妇剥夺”中。 我们的目的是阐明中枢神经系统在控制中扮演的角色 通过调节神经化学的早期发展 释放和细胞代谢并确定大脑区域 参与介导这些神经化学物质和 环境对重要器官生长和功能的影响 正常状态和异常状态。 基本的实验方法利用了多个的评估 开发器官的生理和生化参数 主要是大脑，肺，心脏和肝脏作为改变的指标 这些组织的功能成熟直接由 特定的感觉或营养条件与孕产妇先生 剥夺范式。 这些研究中分析的主要系统 包括代谢（多胺和葡萄糖）内分泌（GH胰岛素，， 和糖皮质激素，即CRF，ACTH，皮质酮）和 神经递质（5-羟色胺，儿茶酚胺，内啡肽和 鸦片）。