KINETICS OF GAS EXCHANGE IN THE PULMONARY CIRCULATION

肺循环中气体交换的动力学

• 批准号: 3365145
• 负责人: ROBERT A KLOCKE
• 金额: $ 16.96万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1995-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3365145
• 关键词: Mammalia; isolation perfusion; plethysmography; pulmonary circulation; pulmonary edema; respiratory airway volume; respiratory gas transport; respiratory hypoxia

DESCRIPTION (adapted from applicant's abstract): The rate of pulmonary gas exchange is affected by many factors but the two principal processes which appear to limit the kinetics of 02 and C02 exchange are the duration of capillary transit time and the rates of intracapillary reactions of the respiratory gases. Therefore the applicant proposes to study the variation in transit times throughout different segments of the pulmonary vasculature and the rate of gas exchange in the intact circulation of the lung. The kinetics of gas exchange would be determined in an isolated, perfused lung preparation contained within a plethysmograph. The lungs would be perfused with buffer by a hydraulic pump which also removes water from the plethysmograph at the same rate to prevent any net volume change. A 2.0 ml bolus of reactant would be injected into the perfusion system. Subsequent gas exchange produces a pressure transient which is related to the corresponding volume of exchanged gas. With knowledge of the concentration profile of a bolus injection, the observed exchange of an inert gas dissolved in a bolus, and the rate of oxygen exchange following injection of a bolus of sodium dithionite, the applicant would determine the distribution of transit times in the arterial and capillary segments of the pulmonary circulation. Injection of suspensions of erythrocytes would indicate the rate of capillary gas exchange.

描述（改编自申请人的摘要）：肺气体发生率 交换受多种因素影响，但影响交换的两个主要过程 似乎限制 02 和 CO2 交换动力学的持续时间是 毛细血管通过时间和毛细血管内反应率 呼吸气体。 因此申请人建议研究变化 穿过肺脉管系统不同部分的传输时间 以及肺完整循环中的气体交换率。 这 气体交换的动力学将在隔离的、灌注的肺中确定 体积描记器内包含的制剂。 肺部会被灌注 通过液压泵进行缓冲，该液压泵还可以去除水 以相同的速率测量体积描记器，以防止任何净体积变化。 2.0毫升 反应物团将被注入灌注系统。 随后的 气体交换产生压力瞬变，该压力瞬变与 相应的交换气体体积。 有了浓度知识 推注曲线，观察到的惰性气体交换 溶解在丸剂中，以及注射后的氧气交换率 连二亚硫酸钠大丸剂，申请人将确定 动脉和毛细血管段的通过时间分布 肺循环。 注射红细胞悬液会 表示毛细管气体交换率。