HIGH RESOLUTION ELECTROCARDIOGRAMS AND ARRHYTHMIA RISK

高分辨率心电图和心律失常风险

• 批准号: 3363509
• 负责人: EDWARD J BERBARI
• 金额: $ 12.9万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3363509
• 关键词: disease /disorder proneness /risk; dogs; electrical potential; electrocardiography; epicardial mapping; heart block; myocardial infarction; tachycardia; ventricular fibrillation

High resolution electrocardiography (HRECG) is used to record electrical activity from diseased and/or damaged regions of the myocardium. These potentials are at the end of the QRS and extend into the ST segment. These "late potentials" have been studied primarily in humans, post-infarction, and are an independent marker for identifying those at risk for ventricular tachycardia. Optimization of the technology used to record and analyze the HRECG is an ongoing theme in our clinical and animal laboratories. The animal laboratory affords the use of invasive means to substantiate the observations of the body surface HRECG and to allow each animal to serve as its own control in cases of intervention. The HRECG has been adopted in many laboratories as a clinical tool, but, several problems remain in which our new approaches may be ideally tested in the animal laboratory. The first problem will focus on the evolution of late potentials following infarction. Secondly, the distribution of late potentials on the body surface will be examined. Current approaches rely on XYZ leads but preliminary data suggest that this may not be adequate. And finally, new frequency domain methods will be used to identify late potentials in the presence of bundle branch block in an effort to provide insights into this long standing problem. There are three key questions being asked: #1. Are there consistent and identifiable characteristics of late potentials which are associated with the degree of severity of arrhythmias following an infarction? #2. What is the spatial distribution on the body surface of cardiac late potentials following myocardial infarction? #3. Are there frequency domain measurements of the signal averaged ECG which improve the detection and identification of late potentials over time domain measurements? Answers to these questions will be obtained by studying a canine infarction model. One group of dogs will be studied four-days post infarct. The intervening period is when late potential characteristics and varying degrees of arrhythmias are evolving. Specially designed Holter recorders will provide an ambulatory HRECG from which late potential measurements can be correlated with the evolving arrhythmic state (question #1). The distribution of late potentials on the thorax will be examined with a 128 channel mapping system which is able to perform body surface signal averaging and record epicardial activation maps. Quantifying the signal and noise levels in each lead should provide answers for question #2. In the acute phase we will examine changes in frequency domain characteristics in dogs with the effects of induced bundle branch to answer question #3.

高分辨率心电图（HRECG）用于记录电气 心肌的患病和/或受损区域的活动。 这些 电势位于QRS的末端，并延伸到ST段。 这些 “迟到”主要是在人类中研究的 并且是识别有室风险的独立标记 心动过速。 用于记录和分析的技术的优化 HRECG是我们临床和动物实验室中持续的主题。 这 动物实验室提供了使用侵入性手段来证实 观察身体表面HRECG，并允许每只动物作为 在干预的情况下，它自己的控制。 HRECG已在 许多实验室作为临床工具，但是仍然存在一些问题 我们的新方法可以在动物实验室中进行理想的测试。 这 第一个问题将集中于后期潜力的演变 梗塞。 其次，在体内的后期电位的分布 将检查表面。 当前的方法取决于XYZ的潜在客户 初步数据表明这可能不足。 最后，新的 频域方法将用于识别该方法 捆绑分支块的存在是为了提供有关此的见解 长期存在的问题。 提出了三个关键问题：＃1。 是否存在后期电位的一致和可识别的特征 与心律失常的严重程度有关 梗塞？ ＃2。 身体表面上的空间分布是什么 心肌梗塞后心脏后期潜力？ ＃3。 在那里 信号平均ECG的频域测量值改善了 检测和识别较晚电位随时间域的检测 测量？ 这些问题的答案将通过研究犬类梗塞来获得 模型。 梗塞后四天将研究一组狗。 这 介入期是较晚的潜在特征和变化 心律不齐程度正在发展。 专门设计的Holter录音机 将提供一个室外HRECG 与不断发展的心律失常状态相关（问题1）。 这 将使用128检查胸部上的晚期电位的分布 能够执行身体表面信号的通道映射系统 平均和记录心外膜激活图。 量化信号 每个潜在客户中的噪声水平应为问题2提供答案。 在 急性阶段我们将检查频域特征的变化 在具有诱发束分支的影响的狗中回答问题3。