HIV ASSOCIATED HEART DISEASE

艾滋病毒相关心脏病

• 批准号: 3359258
• 负责人: ALLAN M ROSS
• 金额: $ 44.59万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3359258
• 关键词: AIDS; AIDS therapy; antiAIDS agent; antiantibody; antiviral agents; arrhythmia; biopsy; cardiotoxin; echocardiography; electrocardiography; heart disorder diagnosis; histopathology; human immunodeficiency virus 1; human subject; immunopathology; immunosuppressive; inflammation; longitudinal human study; myocarditis; myocardium disorder; natural gene amplification; noninvasive diagnosis; nucleic acid hybridization; nucleic acid probes; opportunistic infections; pathology; patient /disease registry; zidovudine

Several lines of evidence have confirmed the association between the syndromes associated with HIV infection and heart disease in humans. Clinically significant congestive cardiomyopathy and echocardiographic abnormalities are commonly found. The first project described in this proposal will develop natural history data regarding the incidence, clinical course, prognostic significance, role of non-invasive evaluation and effects of treatment with anti-viral and immunosuppressive agents on HIV-associated heart disease. This proposal will establish an interdisciplinary cooperative research effort enrolling patients from three District of Columbia academic institutions with diverse patient populations. The research group will contain all the necessary components to study the natural history of HIV-associated heart disease and provide important data regarding the effects of pharmacologic intervention on the development and course of heart disease. Cardiac histopathologic abnormalities in patients with HIV infection have been demonstrated in both post-mortem specimens and endomyocardial biopsy samples. It is not known whether the observed abnormalities are due to 1) direct infection of cardiocytes with HIV, 2) damage from a different infectious agent, or 3) immune-mediated damage of heart cells stimulated by the presence of HIV or other infection. Project 2 of this proposal will evaluate a number of possible mechanisms underlying the development of HIV heart disease.

多项证据证实了两者之间的关联 与艾滋病毒感染和心脏病相关的综合症 人类。 有临床意义的充血性心肌病和 超声心动图异常很常见。 第一个 本提案中描述的项目将开发自然历史数据 关于发病率、临床病程、预后意义， 非侵入性评估的作用和治疗效果 抗病毒药物和免疫抑制剂对 HIV 相关心脏的影响 疾病。 该提案将建立一个跨学科的 合作研究工作招募来自三个地区的患者 拥有不同患者的哥伦比亚学术机构 人口。 研究小组将包含所有必要的人员 研究 HIV 相关心脏自然史的成分 疾病并提供有关其影响的重要数据 药物干预对病情发展和病程的影响 心脏病。 HIV感染者心脏组织病理学异常 两个尸检标本均已证实感染 和心内膜心肌活检样本。 目前尚不清楚是否 观察到的异常是由于 1) 直接感染 感染 HIV 的心肌细胞，2) 来自不同感染的损伤 剂，或 3) 刺激的免疫介导的心脏细胞损伤 由于艾滋病毒或其他感染的存在。 本项目2 提案将评估一些可能的机制 是艾滋病毒心脏病发展的基础。