DETERMINANTS OF OUTCOME OF SEVERE MENTAL DISORDER

严重精神障碍结果的决定因素

• 批准号: 3375146
• 负责人: NORMAN SARTORIUS
• 金额: $ 10.21万
• 依托单位: WORLD HEALTH ORGANIZATION
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1987-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375146
• 关键词: Africa; British Isles; Colombia; Commonwealth of Independent States; India; Japan; Scandinavian country; United States; World Health Organization; culture; disease /disorder proneness /risk; family structure /dynamics; longitudinal human study; mental disorder diagnosis; mental health epidemiology; mental health services; prognosis; schizophrenia; social support network

This application should enable WHO to bring to closure its Collaborative Study on Determinants of Outcome of Severe Mental Disorders, a multi-cultural epidemiological and clinical investigation in which a total of 1,531 persons making a first-in-lifetime contact with any "helping agency" in 13 geographical areas in 10 countries have been identified over a period of two years, and assessed with standardized instruments at intake and at 1-year and 2-year follow-up. Data collection, including on follow-up, has been completed in all research centres, and about 75% of the research schedules have been transferred to WHO Headquarters for processing and analysis (the remainder are expected by the end of May 1985). Basic analyses of the case-finding process, sociodemographic, clinical and diagnostic features of the cohort at initial evaluation, as well as of the age- and sex-specific first-contact incidence of schizophrenia and related disorders, have been performed and a number of preliminary reports prepared. The funds requested should enable WHO to achieve two specific aims: (i) to complete the cleaning, checking and filing of all research data and prepare basic frequency tabulations of all variables; (ii) to carry out most essential data analyses that should enable the completion of a research monograph outlining the major conclusions of the study. Further, to analyses already performed, the outstanding priorities for the period of this grant will be: (a) analyses contributing to a transcultural nosology of schizophrenia (including exploration of factors underlying the differential course and outcome in developing and developed countries); (b) analysis of empirical predictors of course and outcome in schizophrenia; and (c) exploration of culture-related features of the manifestation and course of schizophrenia disorders. The overall strategy of the statistical analysis will be exploratory, but certain specific hypotheses, especially those linked to the question whether multicultural data support the notion of schizophrenia as a group of conditions or favour a single-disease model, will be tested. Statistical analysis will be carried out with preference for simple techniques and log-linear models but multivariate methods will also be applied as appropriate.

该应用程序应该使谁能关闭其协作 研究严重精神疾病结果的决定因素， 多元文化流行病学和临床研究中 1,531人与任何“帮助” “在10个国家的13个地理区域中，已经确定了 两年的时间，并用摄入量的标准化仪器进行评估 并在1年和2年的随访中。 数据收集，包括 随访，所有研究中心都已完成，约有75％ 研究时间表已转移到WHO总部处理 和分析（预计到1985年5月底，其余的）。 基本的 分析病例调查过程，社会人口统计学，临床和 在初步评估时，队列的诊断特征以及 精神分裂症及相关的年龄和性别特异性第一接触率 疾病，已经进行了许多初步报告 准备。 要求的资金应使谁能够实现两个特定的 目的：（i）完成所有研究的清洁，检查和归档 数据并准备所有变量的基本频率表； （ii）到 进行最重要的数据分析，应完成 一项研究专着，概述了研究的主要结论。 此外，为了分析已经进行的分析， 这笔赠款的期限将是：（a）分析促成跨文化的 精神分裂症的疾病学（包括探索依据的因素 发展中国家和发达国家的差异课程和结果）； （b） 当然的经验预测因素和精神分裂症的结果分析； （c）探索表现形式与文化相关的特征 精神分裂症的过程。 统计的总体策略 分析将是探索性的，但是某些特定的假设，尤其是 那些与多元文化数据是否支持概念的问题有关 精神分裂症作为一组疾病或偏爱单疾病模型， 将进行测试。 统计分析将偏爱进行 对于简单的技术和日志线性模型，但多元方法将 也可以适当地应用。

项目成果

Effects of level of socio-economic development on course of non-affective psychosis.

社会经济发展水平对非情感性精神病病程的影响。

• DOI: 10.1192/bjp.171.3.256
• 发表时间: 1997
• 期刊: The British journal of psychiatry : the journal of mental science
• 作者: Varma,VK;Brown,AS;Wig,NN;Tripathi,BM;Misra,AK;Khare,CB;Phookun,HR;Menon,DK;Susser,ES
• 通讯作者: Susser,ES

First-onset schizophrenia in the community: relationship of urbanization with onset, early manifestations and typology.

社区首发精神分裂症：城市化与发病、早期表现和类型的关系。

• DOI: 10.1111/j.1600-0447.1997.tb09944.x
• 发表时间: 1997
• 期刊: Acta psychiatrica Scandinavica
• 影响因子: 6.7
• 作者: Varma,VK;Wig,NN;Phookun,HR;Misra,AK;Khare,CB;Tripathi,BM;Behere,PB;Yoo,ES;Susser,ES
• 通讯作者: Susser,ES