STUDIES OF ATRIAL FLUTTER IN A MODEL

模型中心房扑动的研究

• 批准号: 3354632
• 负责人: ALBERT L WALDO
• 金额: $ 29.95万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1994-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3354632
• 关键词: antiarrhythmic agent; atrial fibrillation; disease /disorder model; dogs; electrocardiography; electrophysiology; heart disorder diagnosis; heart pharmacology; nonhuman therapy evaluation

The long term objectives of this research plan are to apply contemporary electrophysiological and pharmacological techniques to obtain an improved understanding of the mechanisms responsible for atrial flutter and to develop an improved basis for the treatment of atrial flutter. The specific aims of the research plan include the use of the pericarditis canine model of atrial flutter and multiplexing techniques to record simultaneously from 240 electrodes placed on the atrial 1) to characterize the nature of the reentry circuit during atrial flutter; 2) to study the nature of conduction in the center of the atrial flutter reentry circuit; 3) to characterize fully transient entrainment and interruption of atrial flutter; 4) to utilize rapid atrial pacing during sinus rhythm and during atrial flutter (entrainment) to characterize conduction in tissues that constitute the atrial flutter reentry circuit in the right atrium; 5) to characterize conduction at pivot points of activation wave fronts; 6) to study how antiarrhythmic and other selected agents act on the atrial flutter reentry circuit; 7) to test the efficacy of selected interventions for the prevention of inducibility of atrial flutter. The studies will address 15 hypotheses concerned with the maintenance of atrial flutter, the treatment of atrial flutter, and the prevention of atrial flutter. The methods to be used to further characterize and study atrial flutter in this canine model include the use of aseptic surgery to create the sterile pericarditis canine model, the use of standard surgical techniques to expose the heart again following creation of chronic sterile pericarditis; the use of multiplex recording techniques during the various electrophysiologic studies; the use of cardiac pacing techniques; and the use of standard pharmacological techniques for the administration of selected agents. The health relatedness of the project is clear, in that atrial flutter is a well known, clinically troublesome, and poorly understood abnormality affecting patients in significant numbers. The proposed studies should provide important new information to assist in improved understanding and treatment of patients suffering from this abnormality.

该研究计划的长期目标是适用 现代电生理和药理技术 获得对负责心房机制的改进的理解 颤抖并为房屋的治疗增长改善的基础 扑。 研究计划的具体目的包括使用 心心炎犬的房屋颤动和多路复用技术 同时记录位于心房上1的240个电极到1） 表征心房颤动期间的重新进入电路的性质； 2） 研究心房颤动中心的传导性质 再入电路； 3）表征完全瞬态夹带和 心房颤动的中断； 4）在 窦性节奏和心房颤动（夹带）以表征 构成心房颤动回收电路的组织的传导 在右心房； 5）表征在枢轴点的传导 激活波前； 6）研究抗心律失常和其他选定的方式 代理在心房颤动的重新进入电路上作用； 7）测试功效 预防心房诱导性的选定干预措施 扑。 研究将解决与有关的15个假设 维持房间颤音，房屋颤动的处理和 预防心房颤动。 用于进一步的方法 在此犬模型中表征和研究心房颤动包括 使用无菌手术来创建无菌心包炎犬模型， 使用标准手术技术再次暴露心脏 产生慢性无菌心包炎后；使用多重 在各种电生理研究期间记录技术；这 使用心脏起搏技术；以及标准药理的使用 用于施用选定代理的技术。 健康 该项目的相关性很明确，因为心房的颤动是一个井 已知，临床上麻烦且理解不足的异常 影响大量的患者。 拟议的研究应 提供重要的新信息，以帮助提高理解和 治疗患有这种异常的患者。