SODIUM SENSITIVITY OF BLOOD PRESSURE

血压的钠敏感性

• 批准号: 3350311
• 负责人: JOHN H LARAGH
• 金额: $ 50.07万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1989-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3350311
• 关键词: angiotensin /renin /aldosterone hypertension; atrial natriuretic peptide; blood chemistry; calcium metabolism; cardiovascular disorder diagnosis; dietary calcium; dietary supplements; human subject; low salt diet; magnesium; nutrition related tag; renin angiotensin system

Hypertension is a major risk factor for cardiovascular and cerebrovascular disease, and patients with mild hypertension account for the majority of the morbidity. The treatment of these patients is controversial because the results of drug therapy have been disappointing. Dietary sodium restriction and calcium supplementation are interventions that lower blood pressure in some hypertensive patients. The objective of this application is to determine the effectiveness and feasibility of sodium restriction and calcium supplementation in a community based hypertensive population, to determine the interrelationship of these two ions, and to test the ability of several markers to predict the response to these interventions. The markers to be investigated are the activity and reactivity of the renin-angiotensin system, indices of calcium and magnesium metabolism, and atrial natriuretic factor. A random sample (250 patients) will be selected from a large population of hypertensive patients from a Hypertension at the Worksite Treatment Program. A baseline evaluation will vb followed by four week periods of high and low sodium intake, each of which will be preceded by a four week periods of high and low sodium intake, each of which will be preceded by a four week period on a medium sodium intake. The order of high and low sodium diets will be randomly assigned. The same subjects will then enter a placebo controlled crossover study of the effects of oral calcium supplementation, each phase lasting three months. The effects on blood pressure will be assessed by measurement at the worksite, home blood pressure recordings, and 24 hour ambulatory blood pressure monitoring. Twenty-four hour blood pressure monitoring will allow comparison of the effects of the changes in calcium and sodium intake on work and home pressures, providing an index of their effects on blood pressure reactivity. The relationship of sodium sensitivity to calcium sensitivity will be assessed. The ability of baseline levels of plasma renin activity, renin response to acute converting enzyme inhibition, baseline levels of serum ionized calcium and magnesium, and baseline levels of atrial natriuretic factor to predict the response to manipulation of sodium and calcium intakes will be assessed, as will the effect of the dietary manipulations on these parameters. Results of this should have the capability for providing to health care workers new, practical and safe means for blood pressure control in large populations.

高血压是心血管和脑血管的主要危险因素 疾病，轻度高血压患者大部分 发病率。 这些患者的治疗是有争议的，因为 药物疗法的结果令人失望。 饮食钠 限制和补充钙是降低血液的干预措施 一些高血压患者的压力。 此应用的目的 是确定钠限制的有效性和可行性和 在社区高血压人群中补充钙 确定这两个离子的相互关系，并测试能力 几种标记以预测对这些干预措施的反应。 这 要研究的标记是 肾素 - 血管紧张素系统，钙和镁代谢指数，以及 心房亚钠因子。 将从大量人群中选择随机样本（250名患者） 在工作场所治疗中高血压的高血压患者 程序。 基线评估将VB随后四个星期 高和低钠摄入量，每个摄入量将在四个星期之前 高钠摄入量的高时期，每个时期都将在 中钠摄入量四个星期。 高和低的顺序 钠饮食将随机分配。 然后将进入相同的主题 安慰剂控制的口服钙影响的跨界研究 补充，每个阶段持续三个月。 对血液的影响 压力将通过工作场所，家庭血液进行测量来评估 压力记录和24小时卧床血压监测。 24小时的血压监测将允许比较 钙和钠摄入量变化对工作和家庭的影响 压力，提供了其对血压的影响的索引 反应性。 钠敏感性对钙敏感性的关系 将被评估。 血浆肾素活性的基线水平的能力， 肾素对急性转化酶抑制的反应，基线水平 血清离子化钙和镁，以及心房的基线水平 纳地尿素因素预测对钠和操纵的反应 钙摄入量将被评估，饮食的影响也将 对这些参数的操纵。 结果应该具有 为医护人员提供新，实用和安全的能力 大量人群中血压控制的手段。