DIETARY INTERVENTIONS/LIPID/LIPOPROTEIN CHANGES

饮食干预/脂质/脂蛋白变化

• 批准号: 3347442
• 负责人: Zung Vu Tran
• 金额: $ 6.68万
• 依托单位: UNIVERSITY OF NORTHERN COLORADO
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-05-01 至 1990-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3347442
• 关键词: blood lipid; blood lipoprotein; body weight; caloric dietary content; cholesterol; diet therapy; dietary control; dietary lipid; disease /disorder prevention /control; exercise; high density lipoproteins; low density lipoprotein; nutrition related tag; saturated fat; statistics /biometry; triglycerides; unsaturated fats

Dietary interventions can affect serum lipid and lipoprotein levels in a favorable way, especially in reducing levels of total cholesterol, triglycerides, and low density lipoprotein-cholesterol, and in elevating high density lipoprotein-cholesterol. However, the available data are not clear with respect to the magnitude and direction of these changes. Therefore, it is with great difficulty that health professionals can achieve any degree of precision in prescribing the appropriate diet to reduce lipid and lipoprote in risk factors (for coronary artery diseases). Reviews of literature in this area of research have used the traditional approach, that is, chronologically and/or categorically arranging and describing the studies. These traditional research reviews usually result in subjective and unreliable conclusions. Consequently, the relationships among such variables as length of dietary intervention, dietary composition, and body weight changes and the way in which they all contribute to changes in serum lipid and lipoprotein levels remain unclear. As a result, there is a great need for research synthesis that will be statistical and technical as well as narrative and rhetorical to clarify these issues. To accomplish this, meta-analysis methodology will be used to integrate statistically the research findings dealing with the relationships between dietary interventions and changes in serum lipid and lipoprotein levels in humans. Meta-analysis allows for the statistical integration of separate research findings and the determination of the overall magnitude and direction of a given effect. The purposes of this proposed project are: (1) The statistical integration (meta-analysis) of existing research studies on the effects of dietary interventions on changes in serum lipid and lipoprotein levels. (2) The comparison of 3 experimental effects - dietary intervention, exercise intervention, and dietary & exercise intervention as to their relative and unique effects on serum lipid and lipoprotein levels. (3) To provide the scientific community with a clearer perspective of the contributions of dietary interventions to lipid and lipoprotein level changes. This will enable investigators to provide appropriate controls for the many variables that interest with dietary interventions when designing future research. (4) To provide the health care community with findings and recommendations concerning optimal dietary prescriptions to reduce lipid and lipoprotein risk factors.

饮食干预会影响血清脂质和脂蛋白水平 以一种有利的方式，尤其是在降低总水平 胆固醇，甘油三酸酯和低密度脂蛋白 - 胆固醇， 并提高高密度脂蛋白 - 胆固醇。 然而， 相对于大小和 这些变化的方向。 因此，这很难 卫生专业人员可以在 开处方适当的饮食以减少脂质和脂蛋白 危险因素（冠状动脉疾病）。 在这一研究领域的文学评论使用了 传统方法，即按时间顺序和/或绝对的 安排和描述研究。 这些传统研究 评论通常会得出主观和不可靠的结论。 因此，诸如长度的变量之间的关系 饮食干预，饮食组成和体重 变化和他们都为变化做出贡献的方式 血清脂质和脂蛋白水平尚不清楚。 结果，需要研究综合的巨大需求 统计和技术以及叙事和言辞 澄清这些问题。 为此，荟萃分析 方法将用于统计研究 涉及饮食之间关系的发现 干预措施以及血清脂质和脂蛋白水平的变化 人类。 荟萃分析允许统计整合 单独的研究发现和整体的确定 给定效果的大小和方向。 该提议的项目的目的是：（1）统计 现有研究的整合（荟萃分析） 饮食干预对血清脂质变化的影响和 脂蛋白水平。 （2）3个实验效应的比较 - 饮食干预，运动干预以及饮食和运动 干预其对血清脂质的相对和独特影响 和脂蛋白水平。 （3）提供科学界 更清楚地看出饮食的贡献 脂质和脂蛋白水平的干预措施变化。 这会 使研究人员能够为许多人提供适当的控制 设计时饮食干预兴趣的变量 未来的研究。 （4）为医疗保健社区提供 有关最佳饮食的发现和建议 降低脂质和脂蛋白危险因素的处方。