CATHETER TECHNIQUES FOR TREATMENT OF CARDIAC ARRHYTHMIAS

治疗心律失常的导管技术

• 批准号: 3340369
• 负责人: MELVIN M SCHEINMAN
• 金额: $ 9.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3340369
• 关键词: Wolff Parkinson White syndrome; atrium; clinical biomedical equipment; electrocardiography; electrodes; electronic pacemaker; electronic stimulator; epicardial mapping; exercise; heart ventricle; histology; implantable defibrillators; myocardial infarction; tachycardia; ventricular fibrillation

The long-term objectives of this study are to assess the histologic damage and efficacy of ablation of cardiac arrhythmic foci by means of cardiac electroshock. We propose to deliver shocks of varying intensity to different areas of the atria and ventricles and assess the histologic damage. The shocks will be delivered through a standard direct-current defibrillator from an electrode catheter placed in various areas of the heart to a plate on the chest wall. We will also determine change in threshold in different areas of the heart before and after the delivered shocks. We propose to use a canine-infarction model to produce ventricular tachycardia. These dogs will undergo endocardial mapping for tachycardia localization, and attempted ablation by means of one or more delivered shocks. The purpose of these studies are to hopefully extend these procedures for use in patients with cardiac arrhythmias who are refractory to drug treatment.

这项研究的长期目标是评估组织学损害 通过心脏的心律不感染灶消融的功效 电笔。 我们建议将不同强度的冲击激发到 心房和心室的不同区域并评估组织学 损害。 冲击将通过标准的直流传递 放置在位于各个区域的电极导管中的除颤器 心脏到胸壁上的盘子。 我们还将确定变化 交付之前和之后，心脏不同区域的阈值 冲击。 我们建议使用犬界模型产生心室 心动过速。 这些狗会接受心脏心动过速的心内膜映射 本地化，并尝试通过一个或多个交付 冲击。 这些研究的目的是希望将其扩展 难治性心律不齐的患者使用的程序 接受药物治疗。

项目成果

Effects of catheter-delivered electrical discharges near the tricuspid anulus in dogs.

导管在狗三尖瓣环附近传递的放电的影响。

• DOI: 10.1016/s0735-1097(87)80214-0
• 发表时间: 1987
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Ruder,MA;Davis,JC;Eldar,M;Finkbeiner,W;Scheinman,MM
• 通讯作者: Scheinman,MM

Ablation of cardiac tissues by an electrode catheter technique for treatment of ectopic supraventricular tachycardia in adults.

通过电极导管技术消融心脏组织，用于治疗成人异位室上性心动过速。

• DOI: 10.1161/01.cir.74.5.1044
• 发表时间: 1986
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Davis,J;Scheinman,MM;Ruder,MA;Griffin,JC;Herre,JM;Finkebeiner,WE;Chin,MC;Eldar,M
• 通讯作者: Eldar,M

Electrophysiologic and anatomic changes in the atrioventricular junction of dogs after direct-current shocks through tissue fixation catheters.

通过组织固定导管直流电电击后狗房室交界处的电生理和解剖学变化。

• DOI: 10.1016/0002-9149(85)90327-3
• 发表时间: 1985
• 期刊: The American journal of cardiology
• 作者: Scheinman,MM;Bharati,S;Wang,YS;Shapiro,WA;Lev,M
• 通讯作者: Lev,M

Histologic changes and arrhythmogenicity after discharge through transseptal catheter electrode.

通过房间隔导管电极放电后的组织学变化和心律失常性。

• DOI: 10.1161/01.cir.74.3.637
• 发表时间: 1986
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Davis,JC;Finkebeiner,W;Ruder,MA;DiCarloJr,L;Matsubara,T;Chu,W;Winston,SA;Bharati,S;Scheinman,MM;Lev,M
• 通讯作者: Lev,M