ANALYSIS OF MOLECULAR SEQUENCE DATA

分子序列数据分析

• 批准号: 3333458
• 负责人: SAMUEL KARLIN
• 金额: $ 35.84万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1993-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3333458
• 关键词: Epstein Barr virus; Herpesviridae; biomedical equipment purchase; biomedical equipment resource; computer assisted sequence analysis; computer simulation; computers; evolution; genome; mathematical model; model design /development; nucleic acid sequence; protein sequence; transposon /insertion element; varicella zoster virus; virus genetics

This application requests support for our research activities concerned with problems of identifying and classifying patterns within and between nucleic acid and protein sequences. The emphasis is on developing mathematical, statistical and computing concepts and methods to help assess and interpret molecular sequence features. Our research program will concentrate in six main areas. 1) Development of new statistics, means for assessing statistical significance, and methods of data representations for nucleotide and amino acid sequences that can aid in identifying and interpreting molecular sequence relationships; 2) development of efficient and wide-ranging computer algorithms by which to identify significant word relationships among multiple letter sequences; 3) investigation of the nature of codon and amino acid preferences and patterns with respect to different classifications of genes; 4) extensive analysis of the presence or absence of charge concentrations over different categories of genes in many species and possible interpretations for function and structure; 5) pursuit of new approaches for phylogenetic constructions using partial ordering criteria and concepts of consensus trees; and 6) specific comparative sequence analyses to include detailed studies on (a) multigene families (globins, immunoglobulins), (b) the Herpes virus family especially cross studies of the complete Epstein Barr virus and the Varicello Zoster virus genomes, and (c) investigation of the conjunction of a set of retroviruses, hepadnoviruses, and transposon elements. The interplay between theoretical analysis, data analysis, computer algorithms, and interaction with biologists and medical faculty at Stanford has been a key factor in our program. The unique collaboration between our group and members of the biology and medical departments provides an ideal framework for achieving the research objectives defined in this grant.

该申请请求支持我们的研究活动 关注识别和分类模式的问题 核酸和蛋白质序列之间。 这 重点是发展数学，统计和 计算概念和方法来评估和解释 分子序列特征。 我们的研究计划将集中在六个主要领域。 1） 开发新统计数据，用于评估统计的手段 核苷酸的显着性和数据表示方法 和氨基酸序列，可以帮助识别和 解释分子序列关系； 2）开发 高效且广泛的计算机算法 确定多个字母之间的重要单词关系 序列； 3）研究密码子和氨基酸的性质 相对于不同分类的偏好和模式 基因4）对存在或不存在的广泛分析 许多类别基因的电荷浓度 物种和功能和结构的可能解释； 5） 追求使用系统发育结构的新方法 部分订购标准和共识树的概念；和6） 特定的比较序列分析以包括详细研究 在（a）多基因家族（Globins，免疫球蛋白）上，（b） 疱疹病毒家族尤其是跨研究 爱泼斯坦Barr病毒和Varicello带状疱疹病毒基因组和（C） 研究一组逆转录病毒的连接， 肝病病毒和转座子元件。 理论分析，数据分析， 计算机算法以及与生物学家和医疗的互动 斯坦福大学的教师一直是我们计划的关键因素。 这 我们小组与成员之间的独特合作 生物学和医疗部门为 实现本赠款中定义的研究目标。