SECRETION AND ACTION OF DECIDUAL LUTEOTROPIN

蜕膜促黄体激素的分泌和作用

• 批准号: 3321859
• 负责人: GEULA GIBORI
• 金额: $ 9.68万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3321859
• 关键词: embryo implantation; endometrium; estradiol; glycogen; graafian follicles; guinea pigs; hamsters; hormone receptor; hormone regulation /control mechanism; laboratory mouse; laboratory rabbit; laboratory rat; monoclonal antibody; placenta; pregnancy; progesterone; prolactin; pseudopregnancy; radioimmunoassay; somatomammotropin; species difference; steroid hormone biosynthesis; testosterone

The overall objective of this proposal is to gain further insight into the secretion and action of decidual luteotropin, a prolactin- like hormone secreted by the decidual tissue of pregnant and pseudopregnant rats. The first aim will be to establish a direct action of decidual luteotropin on luteal and follicular steroidogenesis. For this investigation, follicles and luteal cells will be either perifused with medium flowing from a decidual cell perifusion, or will be incubated with highly purified hormone. Using in vitro and in vivo approaches, we will investigate the possibility that decidual luteotropin acts locally on decidual and neighboring trophoblastic cells to control glycogen production by the decidua, and steroidogenesis by trophoblastic cells. The third specific aim is designed to determine the ontogeny of decidual luteotropin production throughout the life span of the decidual tissue. To date, with the exception of women and rats, it is not known whether the production of a PRL-like substance is a hormonal function of the decidual tissue. The last aim of this study will be to determine whether in other species in which decidualization accompanies implantation, prolactin-like hormones are produced by the decidual tissue. This would establish the decidua as an endocrine gland in species with hemochorial placentation. We will also investigate the possibility that in some of these species, decidual prolactin possesses luteotropic activity.

该提案的总体目的是获得进一步的见识 进入乳脂蛋白的分泌和作用，一种催乳素 - 就像孕妇的can骨组织分泌的激素和 伪孕大鼠。 第一个目的是建立一个直接 十字形黄质蛋白在黄体和卵泡上的作用 类固醇生成。 对于此研究，卵泡和黄体细胞 将与从决定的单元中流动的中等 促进，或将与高度纯化的激素孵育。 使用体外和体内方法，我们将研究 decIDual le果蛋白在deciDual和 邻近的滋养细胞细胞通过 Decidua和滋养细胞的类固醇发生。 第三 具体目的旨在确定deciDual的个体发育 在决策的整个生命周期 组织。 迄今为止，除了女性和老鼠外，不是 知道PRL样物质的产生是否是 降低组织的激素功能。 最后的目标 研究将是确定是否在其他物种中 植入植入，催乳素样 激素是由决结构组织产生的。 这会 将decidua建立为内分泌腺体的物种 胎儿胎盘。 我们还将调查可能性 在其中一些物种中，deciDual催乳素具有 黄质活性。

项目成果

Protein secretion by mesometrial and antimesometrial rat decidual tissue: evidence for differential gene expression.

子宫内膜和抗子宫内膜大鼠蜕膜组织的蛋白质分泌：差异基因表达的证据。

• DOI: 10.1210/endo-125-2-659
• 发表时间: 1989
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Jayatilak,PG;Puryear,TK;Herz,Z;Fazleabas,A;Gibori,G
• 通讯作者: Gibori,G

Placental-derived regulators and the complex control of luteal cell function.

• DOI: 10.1016/b978-0-12-571144-9.50016-8
• 发表时间: 1988
• 期刊: Recent progress in hormone research
• 作者: G. Gibori;I. Khan;MEREDITH L. Warshaw;M. McLean;T. Puryear;S. Nelson;T. Durkee;S. Azhar;A. Steinschneider;M. Rao