Microfluidic Electrolytic Cells for Routine Synthesis in the Pharmaceutical Industry

用于制药行业常规合成的微流控电解池

• 批准号: EP/G02796X/1
• 负责人: Richard Brown
• 金额: $ 48.52万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG02796X%2F1
• 关键词: Microfluidic; Electrolytic; Cells; Routine; Synthesis

Electrolysis is a synthetic procedure that avoids the use of stoichiometric and toxic/hazardous reagents and is usually carried close to ambient conditions. In addition, there is an extensive literature showing that reactions of interest to the pharmaceutical industry can be carried out with good selectivity. Despite this, and the consequential opportunity to develop more environmentally acceptable synthetic methods, the use of electrolysis is rare because of the need for specialist equipment and know-how. This project brings together a manufacturer of microflow equipment, industrial and academic synthetic organic chemists and electrochemists with experience of both organic electrosynthesis and equipment design/development in order (a) to develop user friendly microflow electrolysis equipment suitable for integration with traditional microflow systems (b) to show that the equipment is well matched to the challenges found in the pharmaceutical industry by optimising several conversions including the selective oxidation of alcohols to carbonyl compounds, the amination of alcohols, and partial fluorination.

电解是一种合成过程，避免使用化学计量和有毒/危险试剂，并且通常在接近环境条件下进行。此外，大量文献表明，制药工业感兴趣的反应可以以良好的选择性进行。尽管如此，以及随之而来的开发更环保的合成方法的机会，由于需要专业设备和专业知识，电解的使用很少。该项目汇集了微流设备制造商、具有有机电合成和设备设计/开发经验的工业和学术合成有机化学家和电化学家，以便 (a) 开发适合与传统微流系统集成的用户友好型微流电解设备 (b) ）表明该设备通过优化多种转化，包括醇选择性氧化为羰基化合物、醇胺化和部分氟化，能够很好地应对制药行业中发现的挑战。

项目成果

Electrochemical Alcohol Oxidation Mediated by TEMPO-like Nitroxyl Radicals.

• DOI: 10.1002/open.201600086
• 发表时间: 2017-02
• 期刊: ChemistryOpen
• 影响因子: 2.3
• 作者: Ciriminna R;Ghahremani M;Karimi B;Pagliaro M
• 通讯作者: Pagliaro M

TEMPO-Mediated Electrooxidation of Primary and Secondary Alcohols in a Microfluidic Electrolytic Cell

• DOI: 10.1002/cssc.201100601
• 发表时间: 2012-02-13
• 期刊: CHEMSUSCHEM
• 影响因子: 8.4
• 作者: Hill-Cousins, Joseph T.;Kuleshova, Jekaterina;Brown, Richard C. D.
• 通讯作者: Brown, Richard C. D.

A voltammetric study of the 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) mediated oxidation of benzyl alcohol in tert-butanol/water

• DOI: 10.1016/j.electacta.2013.09.070
• 发表时间: 2013-12-15
• 期刊: ELECTROCHIMICA ACTA
• 影响因子: 6.6
• 作者: Green, Robert A.;Hill-Cousins, Joseph T.;Leach, Stuart G.
• 通讯作者: Leach, Stuart G.