Enabling Oxidation Reactions on a Large Scale: Combining Electrochemistry with Flow

实现大规模氧化反应：电化学与流动相结合

基本信息

批准号：
EP/G027544/1
负责人：
King Hii
金额：
$ 55.61万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2009
资助国家：
英国
起止时间：
2009 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FG027544%2F1
关键词：
Enabling Oxidation Reactions Large Scale

项目摘要

When a molecule is oxidised, it either loses electrons (increasing its 'oxidation state') or, more commonly in organic chemistry, it gains an oxygen atom from another molecule (the 'oxidant'). Oxygenated molecules are important intermediates for the preparation of complex molecules, including medicinally interesting compounds, and are thus important for phamaceutical production.However, oxidation reactions are often difficult to achieve on a large scale, due to the following reasons:(i) Many oxidants are either toxic, or are thermally unstable materials that are potentially explosive;(ii) Oxidation reactions are by nature exothermic and may involve induction periods - this makes a reaction inherently unsafe, as thermal runaway is unpredictable and thus difficult to control.(iii) Presence of oxidants in organic solvents may generate organic peroxides, which are explosive at a certain limit, and may also cause thermal runaway reactions;(iv) The reaction can be unselective, producing many products, which may be difficult and costly to separate.This project proposes to overcome these problems by designing a new equipment to perform these reactions safely and cleanly, using largely electricity and water to generate oxidants. As the oxidant is generated and consumed immediately, the effective concentration of the reactive oxidant is kept to a minimum during the process, thus eliminating explosive hazards and environmental exposure. We are interested in 'waste free' reactions that produces side products that are environmentally benign, such as water, or in a form that can be recovered and reused (recycled).

当分子被氧化时，它要么丢失电子（增加其“氧化态”），要么更常见于有机化学中，它会从另一个分子（“氧化剂”）中获得氧原子。含氧分子是制备复杂分子（包括药物有趣的化合物）的重要中间体，因此对于小子生产而言很重要。但是，氧化反应通常很难实现，通常很难实现以下原因：（i）许多氧化物是毒性的，氧化是有毒的，并且具有较不稳定的材料，并且具有潜在的概率（II）； II（II）； II（II）；诱导期 - 这使得反应本质上是不安全的，因为热失控是不可预测的，因此难以控制。（iii）有机溶剂中的氧化剂可能会产生有机过氧化物，在一定极限上具有爆炸性，并且可能会导致热反应，并且可能会导致许多产品，这可能会导致许多产物，这可能会导致许多产物，这可能是不可分配的，这可能是构成的。新设备可以安全，干净地进行这些反应，并在很大程度上用电和水生成氧化剂。由于氧化剂是立即产生和消耗的，因此在过程中，反应性氧化剂的有效浓度保持在最低限度，从而消除了爆炸性危害和环境暴露。我们对产生环境良性的副产品（例如水）或可以回收和重复使用的形式（回收）的“无废物”反应感兴趣。