TOTAL SYNTHESIS OF POLYCYCLIC NATURAL PRODUCTS

多环天然产物的全合成

• 批准号: 3305529
• 负责人: CLAYTON H HEATHCOCK
• 金额: $ 17.06万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3305529
• 关键词: alkaloids; chemical synthesis; cyclization; drug design /synthesis /production; heterocyclic polycyclic compound; indoles; molecular rearrangement; strychnine

The research proposed in this document will contribute to our further understanding of how to construct complex organic molecules in an efficient manner. Since the ability to construct complex molecules of any given structure is of underlying significance to medicinal chemistry and of increasing significance to biochemistry and molecular biology, continued development of the field is of fundamental importance. The specific synthetic targets include petrosin, sarain A, aristone, discorhabdin D, and strychnine. The compounds to be synthesized are molecules of nature--alkaloids and acoleginins. The intent is not just to make a compound, but to do it in a way that it will teach something new about the architectural aspect of molecule-building.

本文档中提出的研究将有助于我们进一步 了解如何在一个中构建复杂的有机分子 有效的方式。由于能够构造复杂分子的能力 任何给定的结构都对药物化学具有重要意义 以及对生物化学和分子生物学的重要性越来越重要 该领域的持续发展至关重要。这 特定的合成靶标包括petrosin，sarain A，Aristone， Discorhabdin D和Strychnine。要合成的化合物是 自然的分子 - 类卵生和丙酚素。意图不只是 做一个化合物，但要以某种方式教授东西 关于分子建筑的建筑方面的新知识。